Cancer exosomes and natural killer cells dysfunction: biological roles, clinical significance and implications for immunotherapy

Tumor-derived exosomes (TDEs) play pivotal roles in several aspects of cancer biology. It is now evident that TDEs also favor tumor growth by negatively affecting anti-tumor immunity. As important sentinels of immune surveillance system, natural killer (NK) cells can recognize malignant cells very e...

Full description

Saved in:
Bibliographic Details
Published in:Molecular cancer 2022-01, Vol.21 (1), p.15-15, Article 15
Main Authors: Hosseini, Reza, Sarvnaz, Hamzeh, Arabpour, Maedeh, Ramshe, Samira Molaei, Asef-Kabiri, Leila, Yousefi, Hassan, Akbari, Mohammad Esmaeil, Eskandari, Nahid
Format: Article
Language:English
Subjects:
Adoptive transfer
Animals
Biological Transport
Biomarkers
Breast cancer
Cancer
Cancer immunotherapy
Care and treatment
Cell Communication
Cell Survival
Chemokines
Clinical significance
Cytokines - metabolism
Cytotoxicity
Cytotoxicity, Immunologic
Development and progression
Disease Management
Disease Susceptibility - immunology
Energy Metabolism
Exosomes
Exosomes - metabolism
Gastric cancer
Gene Expression Regulation
Humans
Immunosurveillance
Immunotherapy
Killer cells
Killer Cells, Natural - immunology
Killer Cells, Natural - metabolism
Leukemia
Ligands
Lymphocytes
Lymphoma
Melanoma
Metastases
Metastasis
Natural killer cells
Neoplasms - etiology
Neoplasms - metabolism
Neoplasms - pathology
Neoplasms - therapy
NK Cell Lectin-Like Receptor Subfamily K - metabolism
Oncology, Experimental
Protein Binding
Review
Roles
Signal Transduction
Surveillance equipment
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Tumor-derived exosomes (TDEs) play pivotal roles in several aspects of cancer biology. It is now evident that TDEs also favor tumor growth by negatively affecting anti-tumor immunity. As important sentinels of immune surveillance system, natural killer (NK) cells can recognize malignant cells very early and counteract the tumor development and metastasis without a need for additional activation. Based on this rationale, adoptive transfer of ex vivo expanded NK cells/NK cell lines, such as NK-92 cells, has attracted great attention and is widely studied as a promising immunotherapy for cancer treatment. However, by exploiting various strategies, including secretion of exosomes, cancer cells are able to subvert NK cell responses. This paper reviews the roles of TDEs in cancer-induced NK cells impairments with mechanistic insights. The clinical significance and potential approaches to nullify the effects of TDEs on NK cells in cancer immunotherapy are also discussed.
ISSN:1476-4598
1476-4598
DOI:10.1186/s12943-021-01492-7