Renal Fibrosis and Mitochondrial Damage

First of all, with the chronic inflammation caused by clinicopathologic variables during the process of renal injury, the process of the renal fibrosis will be promoted, and the tubulointerstitial cells will be activated. The kidney is an organ with a high energy requirement with low-glycolytic capa...

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Bibliographic Details
Published in:Chinese medical journal 2018-11, Vol.131 (22), p.2769-2772
Main Authors: Qin, Jiao, Peng, Zhang-Zhe, Li, Qian, Wen, Rui, Tao, Li-Jian
Format: Article
Language:English
Subjects:
Antioxidants
Apoptosis
Cadmium
Cell cycle
Cell death
Cell differentiation
Fibroblasts
Flavonoids
Free radicals
Hazardous materials
Homeostasis
Ideas and Opinions
Insulin
Kidney diseases
Kinases
Lipid peroxidation
Lipids
Mitochondria
Mitochondrial diseases
Oxidation
Pathogenesis
Physiological aspects
Physiology
Proteins
Researchers
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Summary:First of all, with the chronic inflammation caused by clinicopathologic variables during the process of renal injury, the process of the renal fibrosis will be promoted, and the tubulointerstitial cells will be activated. The kidney is an organ with a high energy requirement with low-glycolytic capacity; it depends on the synthetic action of mitochondria to synthesize ATP to meet the energy requirement for the transportation of sodium ions through the renal tubular. Since the restoration of the inner cellular ATP plays a significant role in the recovery of the cell, mitochondrial damage is involved in many nephropathies such as acute kidney injury and renal fibrosis. [...]renal fibrosis is a final stage of a variety of chronic kidney disease progression. Nonetheless, some mechanisms of drug action are still not clear. [...]more researches are need to determine the specific mechanisms of the relationship between mitochondria damage and renal fibrosis and the pharmacological effects of the drugs, in order to provide theoretical support.
ISSN:0366-6999
2542-5641
DOI:10.4103/0366-6999.245272