Predictive factors and treatment challenges in malignant progression of relapsing-remitting multiple sclerosis

Our objective was to uncover the predictive factors that can help anticipate the malignant progression of individuals with Relapsing-Remitting Multiple Sclerosis (RRMS). Additionally, we sought to analyze and compare the response to treatment between patients with benign and malignant forms of RRMS....

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Published in:Heliyon 2024-02, Vol.10 (4), p.e26658-e26658, Article e26658
Main Authors: Ghiasian, Masoud, Bawand, Rashed, Jabarzadeh, Sulmaz, Moradi, Abbas
Format: Article
Language:English
Subjects:
Benign MS
cohort studies
demographic statistics
Disease-modifying therapies
Escalation
magnetism
males
Malignant MS
medical history
phenotype
Prognosis
Relapsing-Remitting Multiple Sclerosis (RRMS)
sclerosis
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Summary:Our objective was to uncover the predictive factors that can help anticipate the malignant progression of individuals with Relapsing-Remitting Multiple Sclerosis (RRMS). Additionally, we sought to analyze and compare the response to treatment between patients with benign and malignant forms of RRMS. This cohort study included RRMS patients categorized as benign (≥10 years since disease onset, Expanded Disability Status Scale (EDSS) ≤ 1) or malignant (≤5 years since disease onset, EDSS ≥6). Patients’ data, including demographics, medical history, treatment, and MRI (Magnetic Resonance Imaging) scans, were collected and statistically analyzed. Among the 254 patients diagnosed with RRMS, 174 were found to have benign RRMS, while the remaining 80 were diagnosed with malignant RRMS. Notably, patients with malignant RRMS exhibited a significantly higher mean age of onset (32.00 ± 7.96 vs. 25.70 ± 17.19; P 
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2024.e26658