The Spectrum of B Cell Functions in Atherosclerotic Cardiovascular Disease

B cells are a core element of the pathophysiology of atherosclerotic cardiovascular disease (ASCVD). Multiple experimental and epidemiological studies have revealed both protective and deleterious functions of B cells in atherosclerotic plaque formation. The spearhead property of B cells that influe...

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Bibliographic Details
Published in:Frontiers in cardiovascular medicine 2022-04, Vol.9, p.864602
Main Authors: Smeets, Diede, Gisterå, Anton, Malin, Stephen G, Tsiantoulas, Dimitrios
Format: Article
Language:English
Subjects:
antibodies
atherosclerosis
B cells
cardiovascular disease
Cardiovascular Medicine
inflammation
lipids
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Summary:B cells are a core element of the pathophysiology of atherosclerotic cardiovascular disease (ASCVD). Multiple experimental and epidemiological studies have revealed both protective and deleterious functions of B cells in atherosclerotic plaque formation. The spearhead property of B cells that influences the development of atherosclerosis is their unique ability to produce and secrete high amounts of antigen-specific antibodies that can act at distant sites. Exposure to an atherogenic milieu impacts B cell homeostasis, cell differentiation and antibody production. However, it is not clear whether B cell responses in atherosclerosis are instructed by atherosclerosis-specific antigens (ASA). Dissecting the full spectrum of the B cell properties in atherosclerosis will pave the way for designing innovative therapies against the devastating consequences of ASCVD.
ISSN:2297-055X
2297-055X
DOI:10.3389/fcvm.2022.864602