Measurement of bradykinesia and chorea in Huntington's Disease using ambulatory monitoring

• Published in: Clinical parkinsonism & related disorders 2023-01, Vol.8, p.100179-100179, Article 100179
• Main Authors: Kotschet, Katya, Osborn, Sarah, Horne, Malcolm
• Format: Article
• Language: English
• Subjects: Biosensors; Daytime sleep; Huntington’s Disease; Movement disorders; Original; Wearable sensors
• ISSN: 2590-1125; 2590-1125
• DOI: 10.1016/j.prdoa.2022.100179

The feasibility of measuring bradykinesia and chorea in Huntington's Disease using a wearable sensor system (Parkinson’s Kinetigraph: PKG) developed for measuring bradykinesia and dyskinesia in Parkinson’s Disease was assessed. Unified Huntington’s Disease Rating Scales (UHDRS) and a PKG were obtained for 25 people with Huntington's Disease. Bradykinesia and Chorea Score were derived from relevant sub-scores of the UHDRS and compared with the PKG’s bradykinesia and dyskinesia scores. The PKG’s daytime sleepiness score was also used. There was good correlation between Chorea Scores and the PKG’s dyskinesia score (Pearson’s ρ = 0.66). Correlation between the Bradykinesia Scores and the PKG’s bradykinesia score was also good (Pearson’s ρ = 0.51) in cases whose PKG scores were in the normal or bradykinetic range. The PKG’s bradykinesia score of 23, which is in the higher range of control subjects, separated participants into those with Independence Score ≥ 80 or