Mono- and Dimeric Xanthones with Anti-Glioma and Anti-Inflammatory Activities from the Ascidian-Derived Fungus Diaporthe sp. SYSU-MS4722

Seven new xanthones, diaporthones A-G ( - ), together with 13 known analogues, including five mono- ( - ) and six dimeric xanthones ( - ), were obtained from the ascidian-derived fungus sp. SYSU-MS4722. Their planar structures were established by extensive spectroscopic analyses, including 1D and 2D...

Full description

Saved in:
Bibliographic Details
Published in:Marine drugs 2022-01, Vol.20 (1), p.51
Main Authors: Chen, Senhua, Guo, Heng, Jiang, Minghua, Wu, Qilin, Li, Jing, Shen, Hongjie, Liu, Lan
Format: Article
Language:English
Subjects:
Animals
anti-glioma activity
Anti-inflammatory agents
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - pharmacology
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Aquatic Organisms
ascidian-derived fungus
Cell Line, Tumor - drug effects
Cell lines
Cell Proliferation - drug effects
Crystallography
Crystallography, X-Ray
Cytotoxicity
Diaporthe
Diaporthe sp
Dimers
Fungi
Glioma
Glioma - pathology
Humans
Inflammation
Inhibitory Concentration 50
Magnetic Resonance Spectroscopy
Marine invertebrates
Mass spectrometry
Mass spectroscopy
Mice
NMR
Nuclear magnetic resonance
Planar structures
RAW 264.7 Cells
Spectrum analysis
Structure-Activity Relationship
Toxicity
Two dimensional analysis
Urochordata
xanthones
Xanthones - chemistry
Xanthones - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Seven new xanthones, diaporthones A-G ( - ), together with 13 known analogues, including five mono- ( - ) and six dimeric xanthones ( - ), were obtained from the ascidian-derived fungus sp. SYSU-MS4722. Their planar structures were established by extensive spectroscopic analyses, including 1D and 2D NMR and high-resolution mass spectrometry (HR-ESIMS). The absolute configurations of - were clearly identified by X-ray crystallographic analysis and calculation of the ECD Spectra. Compounds - showed significant anti-inflammatory activity with IC values between 6.3 and 8.0 μM. In addition, dimeric xanthones ( - ) showed selective cytotoxicity against T98G cell lines with IC values ranging from 19.5 to 78.0 μM.
ISSN:1660-3397
1660-3397
DOI:10.3390/md20010051