Stem cell therapies for autoimmune hepatitis

Autoimmune hepatitis is a chronic inflammatory hepatic disorder which may cause liver fibrosis. Appropriate treatment of autoimmune hepatitis is therefore important. Adult stem cells have been investigated as therapies for a variety of disorders in latest years. Hematopoietic stem cells (HSCs) were...

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Bibliographic Details
Published in:Stem cell research & therapy 2021-07, Vol.12 (1), p.1-386, Article 386
Main Authors: Lotfy, Ahmed, Elgamal, Aya, Burdzinska, Anna, Swelum, Ayman A., Soliman, Reham, Hassan, Ayman A., Shiha, Gamal
Format: Article
Language:English
Subjects:
Adipose tissue
Antibodies
Antigens
Apoptosis
Autoimmune diseases
Autoimmune hepatitis
Bone marrow
Cell interactions
Cell therapy
Cholangitis
Cytokines
Cytotoxicity
Dental pulp
Disease
Exosomes
Fibrosis
Hematopoietic stem cells
Hepatitis
Immune response
Immune system
Ligands
Liver
Liver diseases
Lymphocytes
Mesenchymal stem cell
Mesenchymal stromal cell
Mesenchyme
Multiple sclerosis
Nitric oxide
Review
Stem cells
Tissue engineering
Transplantation
Umbilical cord
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Summary:Autoimmune hepatitis is a chronic inflammatory hepatic disorder which may cause liver fibrosis. Appropriate treatment of autoimmune hepatitis is therefore important. Adult stem cells have been investigated as therapies for a variety of disorders in latest years. Hematopoietic stem cells (HSCs) were the first known adult stem cells (ASCs) and can give rise to all of the cell types in the blood and immune system. Originally, HSC transplantation was served as a therapy for hematological malignancies, but more recently researchers have found the treatment to have positive effects in autoimmune diseases such as multiple sclerosis. Mesenchymal stem cells (MSCs) are ASCs which can be extracted from different tissues, such as bone marrow, adipose tissue, umbilical cord, and dental pulp. MSCs interact with several immune response pathways either by direct cell-to-cell interactions or by the secretion of soluble factors. These characteristics make MSCs potentially valuable as a therapy for autoimmune diseases. Both ASC and ASC-derived exosomes have been investigated as a therapy for autoimmune hepatitis. This review aims to summarize studies focused on the effects of ASCs and their products on autoimmune hepatitis.
ISSN:1757-6512
1757-6512
DOI:10.1186/s13287-021-02464-w