Effects of mediastinal lymph node dissection in colorectal cancer‐related pulmonary metastasectomy

Background The benefits of mediastinal lymph node dissection (MLND) in colorectal cancer‐related pulmonary metastasectomy (PM) have been poorly reported. This study aimed to determine whether MLND affects survival in patients undergoing PM and to identify the prognostic factors for survival. Methods...

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Bibliographic Details
Published in:Thoracic cancer 2021-12, Vol.12 (23), p.3248-3254
Main Authors: Yang, Young Ho, Park, Seong Yong, Kim, Ha Eun, Park, Byung Jo, Lee, Chang Young, Lee, Jin Gu, Kim, Dae Joon, Paik, Hyo Chae
Format: Article
Language:English
Subjects:
Abdomen
Aged
Antigens
Cancer therapies
Colorectal cancer
Colorectal Neoplasms - pathology
Disease-Free Survival
Dissection
Female
Humans
Liver
Lung cancer
Lung Neoplasms - secondary
Lung Neoplasms - surgery
Lymph Node Excision - methods
Lymphatic Metastasis - therapy
Lymphatic system
Male
mediastinal lymph node dissection
Mediastinal Neoplasms - secondary
Mediastinal Neoplasms - surgery
Medical imaging
Medical prognosis
Metastasectomy - methods
Metastasis
Middle Aged
Original
Ostomy
overall survival
Patients
Pneumonectomy - methods
pulmonary metastasectomy
Retrospective Studies
Surgery
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Summary:Background The benefits of mediastinal lymph node dissection (MLND) in colorectal cancer‐related pulmonary metastasectomy (PM) have been poorly reported. This study aimed to determine whether MLND affects survival in patients undergoing PM and to identify the prognostic factors for survival. Methods We retrospectively reviewed 275 patients who had undergone colorectal cancer‐related PM from January 2010 to December 2016. MLND was defined as the resection of at least six mediastinal lymph node stations according to the International Association for the Study of Lung Cancer criteria (N1, ≥3 stations; N2, ≥3 stations). The propensity score matching method was used to reduce bias. Results Thirty‐three (12%) patients underwent MLND, and 13 (4.7%) patients had mediastinal lymph node involvement. This study showed no difference in 5‐year overall survival (no MLND, 52.7% vs. MLND, 53.5%; p = 0.81). On multivariable analysis, negative prognostic factors for overall survival were preoperative carcinoembryonic antigen (CEA) level (p 
ISSN:1759-7706
1759-7714
DOI:10.1111/1759-7714.14196