Analysis of the Curative Effect of Neoadjuvant Therapy on Pancreatic Cancer

The prevalence of pancreatic cancer is sharply increasing recently, which significantly increases the economic burden of the population. At present, the primary treatment of resectable pancreatic cancer is surgical resection, followed by chemotherapy with or without radiation. However, the recurrenc...

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Bibliographic Details
Published in:Frontiers in oncology 2021-08, Vol.11, p.695645-695645
Main Authors: Yang, Liqiong, Bai, Yun, Li, Qing, Chen, Jie, Liu, Fangfang, Weng, Xiechuan, Xu, Fan
Format: Article
Language:English
Subjects:
neoadjuvant chemo-radiotherapy
neoadjuvant chemotherapy
neoadjuvant therapy
Oncology
pancreatic cancer
treatment
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Summary:The prevalence of pancreatic cancer is sharply increasing recently, which significantly increases the economic burden of the population. At present, the primary treatment of resectable pancreatic cancer is surgical resection, followed by chemotherapy with or without radiation. However, the recurrence rates remain high even after R0 resection. This treatment strategy does not distinguish undetected metastatic disease, and it is prone to postoperative complications. Neoadjuvant therapies, including neoadjuvant chemotherapy and radiotherapy, is being increasingly utilized in borderline resectable as well as resectable pancreatic cancer. This review summarized and discussed clinical trials of neoadjuvant therapy for pancreatic cancer, comparing resection rates, outcome measures, and adverse reactions between neoadjuvant chemotherapy and neoadjuvant chemoradiotherapy.
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2021.695645