Injectable Hydrogel-Based Combination Cancer Immunotherapy for Overcoming Localized Therapeutic Efficacy

Various immunotherapeutic agents that can elicit antitumor immune responses have recently been developed with the potential for improved efficacy in treating cancer. However, insufficient delivery efficiency at the tumor site, along with severe side effects after systemic administration of these ant...

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Bibliographic Details
Published in:Pharmaceutics 2022-09, Vol.14 (9), p.1908
Main Authors: Kim, Jeongrae, Choi, Yongwhan, Kim, Dong-Hwee, Yoon, Hong Yeol, Kim, Kwangmeyung
Format: Article
Language:English
Subjects:
Antigens
Antimitotic agents
Antineoplastic agents
Biomedical materials
Cancer
cancer immunotherapy
Cancer therapies
Care and treatment
Chemotherapy
Combined modality therapy
Cytotoxicity
Dosage and administration
drug delivery
Drug delivery systems
Drugs
Efficiency
Hydrogels
Immunotherapy
injectable hydrogel
Light therapy
Metastasis
Methods
Pharmaceutical research
Polyethylene glycol
Radiation therapy
Review
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Summary:Various immunotherapeutic agents that can elicit antitumor immune responses have recently been developed with the potential for improved efficacy in treating cancer. However, insufficient delivery efficiency at the tumor site, along with severe side effects after systemic administration of these anticancer agents, have hindered their therapeutic application in cancer immunotherapy. Hydrogels that can be directly injected into tumor sites have been developed to help modulate or elicit antitumor responses. Based on the biocompatibility, degradability, and controllable mechanochemical properties of these injectable hydrogels, various types of immunotherapeutic agents, such as hydrophobic anticancer drugs, cytokines, antigens, and adjuvants, have been easily and effectively encapsulated, resulting in the successful elicitation of antitumor immune responses and the retention of long-term immunotherapeutic efficacy following administration. This review summarizes recent advances in combination immunotherapy involving injectable hydrogel-based chemoimmunotherapy, photoimmunotherapy, and radioimmunotherapy. Finally, we briefly discuss the current limitations and future perspectives on injectable hydrogels for the effective combination immunotherapy of tumors.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics14091908