Fe Core-Carbon Shell Nanoparticles as Advanced MRI Contrast Enhancer

The aim of this study is to fabricate a hybrid composite of iron (Fe) core-carbon (C) shell nanoparticles with enhanced magnetic properties for contrast enhancement in magnetic resonance imaging (MRI). These new classes of magnetic core-shell nanoparticles are synthesized using a one-step top-down a...

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Bibliographic Details
Published in:Journal of functional biomaterials 2017-10, Vol.8 (4), p.46
Main Authors: Chaudhary, Rakesh P, Kangasniemi, Kim, Takahashi, Masaya, Mohanty, Samarendra K, Koymen, Ali R
Format: Article
Language:English
Subjects:
Biomedical materials
Cavitation
contrast agent
Contrast agents
core-shell nanoparticles
Core-shell particles
Crystal structure
Electron microscopy
Hybrid composites
Iron
Magnetic properties
Magnetic resonance imaging
MRI
Nanoparticles
NMR
Nuclear magnetic resonance
Organic solvents
superparamagnetic
Transmission electron microscopy
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Summary:The aim of this study is to fabricate a hybrid composite of iron (Fe) core-carbon (C) shell nanoparticles with enhanced magnetic properties for contrast enhancement in magnetic resonance imaging (MRI). These new classes of magnetic core-shell nanoparticles are synthesized using a one-step top-down approach through the electric plasma discharge generated in the cavitation field in organic solvents by an ultrasonic horn. Transmission electron microscopy (TEM) observations revealed the core-shell nanoparticles with 10-85 nm in diameter with excellent dispersibility in water without any agglomeration. TEM showed the structural confirmation of Fe nanoparticles with body centered cubic (bcc) crystal structure. Magnetic multi-functional hybrid composites of Fe core-C shell nanoparticles were then evaluated as negative MRI contrast agents, displaying remarkably high transverse relaxivity ( ₂) of 70 mM ·S at 7 T. This simple one-step synthesis procedure is highly versatile and produces desired nanoparticles with high efficacy as MRI contrast agents and potential utility in other biomedical applications.
ISSN:2079-4983
2079-4983
DOI:10.3390/jfb8040046