A Probable Fatal Case of Oleander (Nerium oleander) Poisoning on a Cattle Farm: A New Method of Detection and Quantification of the Oleandrin Toxin in Rumen

Oleander (Nerium oleander) is an ornamental plant common in tropical and sub-tropical regions that is becoming increasingly widespread, even in temperate regions. Oleander poisoning may occur in animals and humans. The main active components contained in the plant are cardiac glycosides belonging to...

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Bibliographic Details
Published in:Toxins 2019-07, Vol.11 (8), p.442
Main Authors: Rubini, Silva, Rossi, Sabina Strano, Mestria, Serena, Odoardi, Sara, Chendi, Sara, Poli, Andrea, Merialdi, Giuseppe, Andreoli, Giuseppina, Frisoni, Paolo, Gaudio, Rosa Maria, Baldisserotto, Anna, Buso, Piergiacomo, Manfredini, Stefano, Govoni, Guido, Barbieri, Stefania, Centelleghe, Cinzia, Corazzola, Giorgia, Mazzariol, Sandro, Locatelli, Carlo Alessandro
Format: Article
Language:English
Subjects:
Animals
Binding sites
Cardiac arrhythmia
Cardiac glycosides
Cattle
Chromatography
Flowers & plants
Glycosides
Hazardous materials
Insects
LC–HRMS
Liquid chromatography
Livestock farming
Mass spectrometry
Mass spectroscopy
Nerium oleander
oleander
Ornamental plants
Poisoning
poisonous plant
Potassium
Rumen
Seeds
Toxicity
Toxins
Tropical environment
Tropical environments
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Summary:Oleander (Nerium oleander) is an ornamental plant common in tropical and sub-tropical regions that is becoming increasingly widespread, even in temperate regions. Oleander poisoning may occur in animals and humans. The main active components contained in the plant are cardiac glycosides belonging to the class of cardenolides that are toxic to many species, from human to insects. This work describes a case of oleander poisoning that occurred on a small cattle farm and resulted in the fatality of all six resident animals. Furthermore, the investigation of the poisonous agent is described, with particular focus on the characterization of the oleandrin toxin that was recovered from the forage and rumen contents. The innovation of this study is the first description of the detection and quantification of the oleandrin toxin by liquid chromatography-high resolution mass spectrometry (LC-HRMS) in rumen.
ISSN:2072-6651
2072-6651
DOI:10.3390/toxins11080442