Microfluidic Device Directly Fabricated on Screen-Printed Electrodes for Ultrasensitive Electrochemical Sensing of PSA

How to fabricate scale low-cost microfluidic device for detection of biomarkers owns a great requirement. Herein, it is for the first time reported that a new microfluidic device based on bonding polydimethylsiloxane microfluidic channels onto the substrate of a screen-printed electrode with coating...

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Bibliographic Details
Published in:Nanoscale research letters 2019-02, Vol.14 (1), p.71-7, Article 71
Main Authors: Chen, Shouhui, Wang, Zhihua, Cui, Xinyuan, Jiang, Linlei, Zhi, Yuee, Ding, Xianting, Nie, Zhihong, Zhou, Pei, Cui, Daxiang
Format: Article
Language:English
Subjects:
Biomarkers
Chemistry and Materials Science
Coated electrodes
Detection
Electrochemical sensor
Electrochemistry
Electrodes
Environmental monitoring
Linearity
Low cost
Mass production
Materials Science
Microfluidic devices
Microfluidics
Molecular Medicine
Nano Express
Nanochemistry
Nanoscale Science and Technology
Nanotechnology
Nanotechnology and Microengineering
Polydimethylsiloxane
Prostate
Prostate-specific antigen
PSA
Screen-printed electrode
Substrates
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Summary:How to fabricate scale low-cost microfluidic device for detection of biomarkers owns a great requirement. Herein, it is for the first time reported that a new microfluidic device based on bonding polydimethylsiloxane microfluidic channels onto the substrate of a screen-printed electrode with coating glass solution was fabricated for electrochemical sensing of prostate-specific antigen (PSA). Compared to traditional microfabrication processes, this method is simple, fast, low cost, and also suitable for mass production. The prepared screen-printed electrode-based microfluidic device (CASPE-MFD) was used for the detection of the PSA in human serum. The prepared CASPE-MFD had a detection limit of 0.84 pg/mL (25.8 fM) and a good linearity with PSA concentration ranging from 0.001 to 10 ng/mL, which showed a great promise platform toward the development of miniaturized, low-cost electrochemical microfluidic device for use in human health, environmental monitoring, and other applications.
ISSN:1931-7573
1556-276X
DOI:10.1186/s11671-019-2857-6