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Microfluidic Device Directly Fabricated on Screen-Printed Electrodes for Ultrasensitive Electrochemical Sensing of PSA
How to fabricate scale low-cost microfluidic device for detection of biomarkers owns a great requirement. Herein, it is for the first time reported that a new microfluidic device based on bonding polydimethylsiloxane microfluidic channels onto the substrate of a screen-printed electrode with coating...
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Published in: | Nanoscale research letters 2019-02, Vol.14 (1), p.71-7, Article 71 |
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creator | Chen, Shouhui Wang, Zhihua Cui, Xinyuan Jiang, Linlei Zhi, Yuee Ding, Xianting Nie, Zhihong Zhou, Pei Cui, Daxiang |
description | How to fabricate scale low-cost microfluidic device for detection of biomarkers owns a great requirement. Herein, it is for the first time reported that a new microfluidic device based on bonding polydimethylsiloxane microfluidic channels onto the substrate of a screen-printed electrode with coating glass solution was fabricated for electrochemical sensing of prostate-specific antigen (PSA). Compared to traditional microfabrication processes, this method is simple, fast, low cost, and also suitable for mass production. The prepared screen-printed electrode-based microfluidic device (CASPE-MFD) was used for the detection of the PSA in human serum. The prepared CASPE-MFD had a detection limit of 0.84 pg/mL (25.8 fM) and a good linearity with PSA concentration ranging from 0.001 to 10 ng/mL, which showed a great promise platform toward the development of miniaturized, low-cost electrochemical microfluidic device for use in human health, environmental monitoring, and other applications. |
doi_str_mv | 10.1186/s11671-019-2857-6 |
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Herein, it is for the first time reported that a new microfluidic device based on bonding polydimethylsiloxane microfluidic channels onto the substrate of a screen-printed electrode with coating glass solution was fabricated for electrochemical sensing of prostate-specific antigen (PSA). Compared to traditional microfabrication processes, this method is simple, fast, low cost, and also suitable for mass production. The prepared screen-printed electrode-based microfluidic device (CASPE-MFD) was used for the detection of the PSA in human serum. The prepared CASPE-MFD had a detection limit of 0.84 pg/mL (25.8 fM) and a good linearity with PSA concentration ranging from 0.001 to 10 ng/mL, which showed a great promise platform toward the development of miniaturized, low-cost electrochemical microfluidic device for use in human health, environmental monitoring, and other applications.</description><identifier>ISSN: 1931-7573</identifier><identifier>EISSN: 1556-276X</identifier><identifier>DOI: 10.1186/s11671-019-2857-6</identifier><identifier>PMID: 30820698</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biomarkers ; Chemistry and Materials Science ; Coated electrodes ; Detection ; Electrochemical sensor ; Electrochemistry ; Electrodes ; Environmental monitoring ; Linearity ; Low cost ; Mass production ; Materials Science ; Microfluidic devices ; Microfluidics ; Molecular Medicine ; Nano Express ; Nanochemistry ; Nanoscale Science and Technology ; Nanotechnology ; Nanotechnology and Microengineering ; Polydimethylsiloxane ; Prostate ; Prostate-specific antigen ; PSA ; Screen-printed electrode ; Substrates</subject><ispartof>Nanoscale research letters, 2019-02, Vol.14 (1), p.71-7, Article 71</ispartof><rights>The Author(s). 2019</rights><rights>Nanoscale Research Letters is a copyright of Springer, (2019). All Rights Reserved. © 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). 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Herein, it is for the first time reported that a new microfluidic device based on bonding polydimethylsiloxane microfluidic channels onto the substrate of a screen-printed electrode with coating glass solution was fabricated for electrochemical sensing of prostate-specific antigen (PSA). Compared to traditional microfabrication processes, this method is simple, fast, low cost, and also suitable for mass production. The prepared screen-printed electrode-based microfluidic device (CASPE-MFD) was used for the detection of the PSA in human serum. The prepared CASPE-MFD had a detection limit of 0.84 pg/mL (25.8 fM) and a good linearity with PSA concentration ranging from 0.001 to 10 ng/mL, which showed a great promise platform toward the development of miniaturized, low-cost electrochemical microfluidic device for use in human health, environmental monitoring, and other applications.</description><subject>Biomarkers</subject><subject>Chemistry and Materials Science</subject><subject>Coated electrodes</subject><subject>Detection</subject><subject>Electrochemical sensor</subject><subject>Electrochemistry</subject><subject>Electrodes</subject><subject>Environmental monitoring</subject><subject>Linearity</subject><subject>Low cost</subject><subject>Mass production</subject><subject>Materials Science</subject><subject>Microfluidic devices</subject><subject>Microfluidics</subject><subject>Molecular Medicine</subject><subject>Nano Express</subject><subject>Nanochemistry</subject><subject>Nanoscale Science and 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Herein, it is for the first time reported that a new microfluidic device based on bonding polydimethylsiloxane microfluidic channels onto the substrate of a screen-printed electrode with coating glass solution was fabricated for electrochemical sensing of prostate-specific antigen (PSA). Compared to traditional microfabrication processes, this method is simple, fast, low cost, and also suitable for mass production. The prepared screen-printed electrode-based microfluidic device (CASPE-MFD) was used for the detection of the PSA in human serum. The prepared CASPE-MFD had a detection limit of 0.84 pg/mL (25.8 fM) and a good linearity with PSA concentration ranging from 0.001 to 10 ng/mL, which showed a great promise platform toward the development of miniaturized, low-cost electrochemical microfluidic device for use in human health, environmental monitoring, and other applications.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>30820698</pmid><doi>10.1186/s11671-019-2857-6</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-4513-905X</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Biomarkers Chemistry and Materials Science Coated electrodes Detection Electrochemical sensor Electrochemistry Electrodes Environmental monitoring Linearity Low cost Mass production Materials Science Microfluidic devices Microfluidics Molecular Medicine Nano Express Nanochemistry Nanoscale Science and Technology Nanotechnology Nanotechnology and Microengineering Polydimethylsiloxane Prostate Prostate-specific antigen PSA Screen-printed electrode Substrates |
title | Microfluidic Device Directly Fabricated on Screen-Printed Electrodes for Ultrasensitive Electrochemical Sensing of PSA |
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