Presenilins and mitochondria-an intriguing link: mini-review

This review uncovers the intricate relationship between presenilins, calcium, and mitochondria in the context of Alzheimer's disease (AD), with a particular focus on the involvement of presenilin mutations in mitochondrial dysfunction. So far, it is unclear whether the impairment of mitochondri...

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Bibliographic Details
Published in:Frontiers in neuroscience 2023-07, Vol.17, p.1249815-1249815
Main Authors: Makarov, Mark, Kushnireva, Liliia, Papa, Michele, Korkotian, Eduard
Format: Article
Language:English
Subjects:
Alzheimer's disease
Autophagy
Calcium homeostasis
Endoplasmic reticulum
Homeostasis
Hypotheses
Kinases
Membranes
Mitochondria
mitochondria associated membranes
Mitochondrial DNA
Mutation
neurodegeneration
Neurodegenerative diseases
Neuroscience
Pathogenesis
Phosphorylation
Presenilin
presenilins
Proteins
Secretase
spine apparatus
β-Amyloid
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Description
Summary:This review uncovers the intricate relationship between presenilins, calcium, and mitochondria in the context of Alzheimer's disease (AD), with a particular focus on the involvement of presenilin mutations in mitochondrial dysfunction. So far, it is unclear whether the impairment of mitochondrial function arises primarily from damage inflicted by -amyloid upon mitochondria or from the disruption of calcium homeostasis due to presenilins dysfunctions. The roles of presenilins in mitophagy, autophagy, mitochondrial dynamics, and many other functions, non- -secretase related, also require close attention in future research. Resolution of contradictions in understanding of presenilins cellular functions are needed for new effective therapeutic strategies for AD.
ISSN:1662-4548
1662-453X
1662-453X
DOI:10.3389/fnins.2023.1249815