The association of prealbumin, transferrin, and albumin with immunosenescence among elderly males

As people get older, the innate and acquired immunity of the elderly are affected, resulting in immunosenescence. Prealbumin (PAB), transferrin (TRF), and albumin (ALB) are commonly used markers to monitor protein energy malnutrition (PEM). However, their relationship with the immune system has not...

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Bibliographic Details
Published in:The aging male 2024-12, Vol.27 (1), p.2310308-2310308
Main Authors: Zhang, Ren-Dan, Jiang, Shi-Qin, Yan, Feng-Juan, Ruan, Lei, Zhang, Cun-Tai, Quan, Xiao-Qing
Format: Article
Language:English
Subjects:
Aged
Aging
albumin
Biomarkers
Blood Proteins
CD28 Antigens
Humans
Immune system
Immunosenescence
Male
Malnutrition
Mens health
Older people
Prealbumin
protein energy malnutrition
Proteins
Transferrin
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Summary:As people get older, the innate and acquired immunity of the elderly are affected, resulting in immunosenescence. Prealbumin (PAB), transferrin (TRF), and albumin (ALB) are commonly used markers to monitor protein energy malnutrition (PEM). However, their relationship with the immune system has not been fully explored. In our study, a total of 93 subjects (≥65 years) were recruited from Tongji Hospital between January 2015 and February 2017. According to the serum levels of these proteins (PAB, TRF, and ALB), we divided the patients into the high serum protein group and the low serum protein group. Then, we compared the percent expression of lymphocyte subsets between two groups. All the low serum protein groups (PAB, TRF, and ALB) had significant decreases in the percentage of CD4+ cells, CD3 CD28 cells, CD4 CD28 cells and significant increases in the percentage of CD8 cells, CD8 CD28 cells. PAB, TRF, and ALB levels revealed positive correlations with CD4/CD8 ratio, proportions of CD4 cells, CD3 CD28 cells, CD4 CD28 cells, and negative correlation with proportions of CD8 cells, CD8 CD28 cells. This study suggested PAB, TRF, and ALB could be used as immunosenescence indicators. PEM might accelerate the process of immunosenescence in elderly males.
ISSN:1368-5538
1473-0790
DOI:10.1080/13685538.2024.2310308