Potential Effects of Oral Isotretinoin on Growth Plate and Height

Longitudinal growth and puberty are the result of a complex interaction of genetic, hormonal, nutritional, and environmental factors. Acne vulgaris is a chronic disease of the pilosebaceous unit that affects 85% of adolescents worldwide. Isotretinoin is a synthetic vitamin A derivative drug effectiv...

Full description

Saved in:
Bibliographic Details
Published in:Endocrines 2023-04, Vol.4 (2), p.281-292
Main Authors: Cardoso-Demartini, Adriane A., Boguszewski, Cesar Luiz, Boguszewski, Margaret C. S.
Format: Article
Language:English
Subjects:
Acids
Acne
Antibiotics
Apoptosis
Cell cycle
Cell growth
Child development
Drug dosages
growth
Hormones
Insulin
Insulin-like growth factors
isotretinoin
Kinases
Pathogenesis
Pediatrics
Proteins
Puberty
retinoid
Skin
Triglycerides
Vitamin A
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Longitudinal growth and puberty are the result of a complex interaction of genetic, hormonal, nutritional, and environmental factors. Acne vulgaris is a chronic disease of the pilosebaceous unit that affects 85% of adolescents worldwide. Isotretinoin is a synthetic vitamin A derivative drug effective and is widely employed for the treatment of moderate and severe acne vulgaris. Premature epiphyseal closure has been reported in patients with neuroblastoma treated with high doses of isotretinoin as well as in patients with acne receiving lower doses. Although the mechanisms for these effects are not clear, it has been suggested that isotretinoin may have a negative impact on the GH-IGF-I axis, leading to a reduction in IGF-I and IGFBP3 serum levels. Although many of the isotretinoin adverse effects in pediatric patients are transient, premature epiphyseal closure and bone abnormalities can lead to transient abnormalities and permanent deformities with a negative impact on longitudinal growth and final height. The aim of this study was to review the potential effects of oral isotretinoin on the growth plate and growth during childhood and adolescence.
ISSN:2673-396X
2673-396X
DOI:10.3390/endocrines4020023