Changes in Umbilico-Placental Circulation during Prolonged Intact Cord Resuscitation in a Lamb Model

Some previous studies reported a benefit to cardiopulmonary transition at birth when starting resuscitation maneuvers while the cord was still intact for a short period of time. However, the best timing for umbilical cord clamping in this condition is unknown. The aim of this study was to explore th...

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Bibliographic Details
Published in:Children (Basel) 2021-04, Vol.8 (5), p.337
Main Authors: Le Duc, Kévin, Aubry, Estelle, Mur, Sébastien, Besengez, Capucine, Garabedian, Charles, De Jonckheere, Julien, Storme, Laurent, Sharma, Dyuti
Format: Article
Language:English
Subjects:
Adaptation
Babies
Blood
Catheters
Childrens health
Coronary vessels
delayed cord clamping
Experiments
intact cord resuscitation
Life Sciences
Newborn babies
Pediatrics
Umbilical cord
umbilico–placental circulation
Veins & arteries
Ventilation
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Summary:Some previous studies reported a benefit to cardiopulmonary transition at birth when starting resuscitation maneuvers while the cord was still intact for a short period of time. However, the best timing for umbilical cord clamping in this condition is unknown. The aim of this study was to explore the duration of effective umbilico-placental circulation able to promote cardiorespiratory adaptation at birth during intact cord resuscitation. Umbilico-placental blood flow and vascular resistances were measured in an experimental neonatal lamb model. After a C-section delivery, the lambs were resuscitated ventilated for 1 h while the cord was intact. The maximum and mean umbilico-placental blood flow were respectively 230 ± 75 and 160 ± 12 mL·min during the 1 h course of the experiment. However, umbilico-placental blood flow decreased and vascular resistance increased significantly 40 min after birth ( < 0.05). These results suggest that significant cardiorespiratory support can be provided by sustained placental circulation for at least 1 h during intact cord resuscitation.
ISSN:2227-9067
2227-9067
DOI:10.3390/children8050337