Polyethylene glycol (PEG-400): an efficient and recyclable reaction medium for the synthesis of pyrazolo[3,4-b]pyridin-6(7H)-one derivatives

A mild and efficient synthesis of pyrazolo[3,4-b]pyridine-6(7H)-one derivatives via a three-component reaction of an aldehyde, Meldrum's acid and 3-methyl-1H-pyrazol-5-amine using recyclable polyethylene glycol (PEG)-400 as a reaction medium is described. This method has the advantages of acces...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2013-10, Vol.18 (11), p.13139-13147
Main Authors: Zhong, Xiaoxing, Dou, Guolan, Wang, Deming
Format: Article
Language:English
Subjects:
Acids
Aldehydes
Aldehydes - chemistry
Alzheimer's disease
aqueous media
Dioxanes - chemistry
Polyethylene glycol
Polyethylene Glycols - chemistry
Pyrazoles - chemistry
pyrazolo[3,4-b]pyridine-6(7H)-one
Pyridines - chemistry
recyclable polyethylene glycol
Solvents
synthesis
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Summary:A mild and efficient synthesis of pyrazolo[3,4-b]pyridine-6(7H)-one derivatives via a three-component reaction of an aldehyde, Meldrum's acid and 3-methyl-1H-pyrazol-5-amine using recyclable polyethylene glycol (PEG)-400 as a reaction medium is described. This method has the advantages of accessible starting materials, good yields, mild reaction conditions and begin environmentally friendly.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules181113139