In Vivo Ergogenic Properties of the Bifidobacterium longum OLP-01 Isolated from a Weightlifting Gold Medalist

In recent years, probiotics of human origin have shown superior results and performance compared to probiotics from plant or dairy sources, in both in vitro and animal studies. Towards this end, the current study was conducted to explore the ergogenic properties of OLP-01 isolated from the intestina...

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Bibliographic Details
Published in:Nutrients 2019-08, Vol.11 (9), p.2003
Main Authors: Lee, Mon-Chien, Hsu, Yi-Ju, Chuang, Hsiao-Li, Hsieh, Pei-Shan, Ho, Hsieh-Hsun, Chen, Wei-Ling, Chiu, Yen-Shuo, Huang, Chi-Chang
Format: Article
Language:English
Subjects:
Animals
Bacteria
Bifidobacterium - metabolism
Biomarkers - blood
Bone surgery
Competitive Behavior
Diabetes
Endurance
Energy Metabolism
exercise performance
Fatigue
Female
Gastrointestinal Microbiome
Gene expression
gold medal
Grip strength
Humans
Intestines - microbiology
Laboratory animals
Lactic acid
Male
Metabolism
Metabolites
Mice, Inbred ICR
Microbiota
Mitochondria
Muscle Fatigue
Muscle Strength
OLP-01
olympics
Physical Endurance
Physical training
Physiology
probiotic
Probiotics
R&D
Research & development
Time Factors
Trend analysis
Weight Lifting
Weightlifting
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Summary:In recent years, probiotics of human origin have shown superior results and performance compared to probiotics from plant or dairy sources, in both in vitro and animal studies. Towards this end, the current study was conducted to explore the ergogenic properties of OLP-01 isolated from the intestinal microbiome of the gold medalist from the 2008 Beijing Olympics women's 48 kg weightlifting competition. Male Institute of Cancer Research (ICR) mice were divided into four groups ( = 10 per group) and orally administered OLP-01 for 4 weeks at 0 (vehicle), 2.05 × 10 (OLP-01-1X), 4.10 × 10 (OLP-01-2X), and 1.03 × 10 (OLP-01-5X) CFU/kg/day. Physical performance tests including grip strength and endurance time were measured, with OLP-01 supplementation dose-dependently elevating grip strength and endurance. The anti-fatigue activity levels of serum lactate, ammonia, glucose, blood urea nitrogen (BUN), and creatine kinase (CK) were measured after an acute exercise challenge, and OLP-01 was found to significantly decrease lactate, ammonia, and CK levels. OLP-01 treatment was also found to significantly increase the resting levels of both hepatic and muscular glycogen, an indicator of energy storage. Supplementation by OLP-01 showed no subchronic toxic effects while supporting many health-promoting, performance-improving, and fatigue-ameliorating functions.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu11092003