The medium-chain fatty acid decanoic acid reduces oxidative stress levels in neuroblastoma cells

Enhanced oxidative stress is a contributing factor in the pathogenesis of several neurodegenerative disorders such as Alzheimer´s disease. Beneficial effects have been demonstrated for medium-chain fatty acids (MCFAs) nutritionally administered as medium-chain triglycerides (MCTs) or coconut oil (CO...

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Bibliographic Details
Published in:Scientific reports 2021-03, Vol.11 (1), p.6135-6135, Article 6135
Main Authors: Mett, Janine, Müller, Uli
Format: Article
Language:English
Subjects:
631/378
631/80
Catalase
Cell death
Cell lines
Coconut oil
Cognitive ability
Energy sources
Fatty acids
Gene expression
Humanities and Social Sciences
Hydrogen peroxide
Ketones
Lecithin
multidisciplinary
Neuroblastoma
Neuroblasts
Neurodegenerative diseases
Oxidative stress
Phosphatidylcholine
Science
Science (multidisciplinary)
Triglycerides
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Summary:Enhanced oxidative stress is a contributing factor in the pathogenesis of several neurodegenerative disorders such as Alzheimer´s disease. Beneficial effects have been demonstrated for medium-chain fatty acids (MCFAs) nutritionally administered as medium-chain triglycerides (MCTs) or coconut oil (CO). The observed effects on cognitive impairment are generally attributed to the hepatic metabolism of MCFAs, where resulting ketone bodies serve as an alternate energy source to compensate for the impaired glucose utilisation in the human brain. Here we show that the saturated MCFA decanoic acid (10:0) reduces the oxidative stress level in two different neuroblastoma cell lines. Phosphatidylcholine (PC) containing decanoic acid (10:0) (PC10:0/10:0) reduced the cellular H 2 O 2 release in comparison to solvent, L-α-Glycerophosphorylcholine and PC containing the long-chain fatty acid (LCFA) arachidic acid (20:0). This effect seems to be at least partially based on an upregulation of catalase activity, independent of alterations in catalase gene expression. Further, PC10:0/10:0 decreased the intracellular oxidative stress level and attenuated the H 2 O 2 -induced cell death. It did not affect the level of the ketone body β-hydroxybutyrate (βHB). These results indicate that decanoic acid (10:0) and possibly MCFAs in general directly reduce oxidative stress levels independent of ketone levels and thus may promote neuronal health.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-85523-9