Syndecan-1 Expression Is Increased in the Aortic Wall of Patients with Type 2 Diabetes but Is Unrelated to Elevated Fasting Plasma Glucagon-Like Peptide-1

• Published in: Biomedicines 2021-06, Vol.9 (6), p.697
• Main Authors: Ntika, Stelia, Tracy, Linda M, Franco-Cereceda, Anders, Björck, Hanna M, Krizhanovskii, Camilla
• Format: Article
• Language: English
• Subjects: Abdomen; adventitia; Aneurysms; Animal models; Antibodies; Aortic valve; Biotechnology; Coronary vessels; Cytokines; Diabetes; Diabetes mellitus (non-insulin dependent); Enzymes; Fasting; Gelatinase A; Glucagon; Glucagon-like peptide 1; Inflammation; Kinases; Laboratories; Macrophages; Medicin och hälsovetenskap; Patients; Peptides; Plasma; Proteins; Proteolysis; Surgery; Syndecan; syndecan-1; thoracic aortic aneurysm; Thorax; Tumor necrosis factor-TNF; type 2 diabetes
• ISSN: 2227-9059; 2227-9059
• DOI: 10.3390/biomedicines9060697

A reduced prevalence of a thoracic aortic aneurysm (thoracic AA) is observed in type 2 diabetes (T2D). Glucagon-like peptide-1 (GLP-1)/GLP-1-based anti-diabetic therapy has indicated protective effects in thoracic AA and regulates the processes controlling the vascular tissue expression of Syndecan-1 (Sdc-1). Sdc-1 expression on macrophages infiltrating the aortic tissue contributes to a counter-regulatory response to thoracic AA formation in animal models through the interplay with inflammation/proteolytic activity. We hypothesized that elevated fasting plasma GLP-1 (fpGLP-1) increases the aortic Sdc-1 expression in T2D, which may contribute to a reduced prevalence of thoracic AA. Consequently, we determined whether T2D/thoracic AA associates with an altered Sdc-1 expression in the aortic tissue and the possible associations with fpGLP-1 and inflammation/proteolytic activity. From a cohort of surgical patients with an aortic valve pathology, we compared different disease groups (T2D/thoracic AA) with the same sub-cohort group of controls (patients without T2D and thoracic AA). The MMP-2 activity and Sdc-1, GLP-1R and CD68 expression were analyzed in the aortic tissue. GLP-1, Sdc-1 and cytokines were analyzed in the plasma. The aortic Sdc-1 expression was increased in T2D patients but did not correlate with fpGLP-1. Thoracic AA was associated with an increased aortic expression of Sdc-1 and the macrophage marker CD68. CD68 was not detected in T2D. In conclusion, an increased aortic Sdc-1 expression may contribute to a reduced prevalence of thoracic AA in T2D.