The emerging modulators of non-coding RNAs in diabetic wound healing

Diabetic wound healing is a complex physiological process often hindered by the underlying metabolic dysfunctions associated with diabetes. Despite existing treatments, there remains a critical need to explore innovative therapeutic strategies to improve patient outcomes. This article comprehensivel...

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Published in:Frontiers in endocrinology (Lausanne) 2024-10, Vol.15, p.1465975
Main Authors: Aghayants, Sis, Zhu, Jinjin, Yu, Jing, Tao, Rui, Li, Sicheng, Zhou, Shengzhi, Zhou, Yunhua, Zhu, Zhanyong
Format: Article
Language:English
Subjects:
Animals
circular RNA
Diabetes Complications - genetics
Diabetes Complications - metabolism
Diabetes Mellitus - genetics
Diabetes Mellitus - metabolism
diabetic foot ulcer
diabetic wound
Endocrinology
Humans
long non-coding RNA
microRNA
MicroRNAs - genetics
MicroRNAs - metabolism
non-coding RNA
RNA, Circular - genetics
RNA, Long Noncoding - genetics
RNA, Untranslated - genetics
Wound Healing - genetics
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Summary:Diabetic wound healing is a complex physiological process often hindered by the underlying metabolic dysfunctions associated with diabetes. Despite existing treatments, there remains a critical need to explore innovative therapeutic strategies to improve patient outcomes. This article comprehensively examines the roles of non-coding RNAs (ncRNAs), specifically microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), in regulating key phases of the wound healing process: inflammation, angiogenesis, re-epithelialization, and tissue remodeling. Through a deep review of current literature, we discuss recent discoveries of ncRNAs that have been shown to either promote or impair the wound healing process in diabetic wound healing, which were not covered in earlier reviews. This review highlights the specific mechanisms by which these ncRNAs impact cellular behaviors and pathways critical to each healing stage. Our findings indicate that understanding these recently identified ncRNAs provides new insights into their potential roles in diabetic wound healing, thereby contributing valuable knowledge for future research directions in this field.
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2024.1465975