Replacing oxamniquine by praziquantel against Schistosoma mansoni infection in a rural community from the sugar-cane zone of Northeast Brazil: an epidemiological follow-up

A group of 52 villagers was followed-up for three years regarding Schistosoma mansoni infection. All villagers were periodically surveyed by the Kato-Katz method. In March 1997 and March 1998 the positives were treated with oxamniquine (15-20 mg/kg), and in March 1999, with praziquantel (60 mg/kg)....

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Bibliographic Details
Published in:Memórias do Instituto Oswaldo Cruz 2001-01, Vol.96 Suppl (suppl), p.165-167
Main Authors: Beck, L, Favre, T C, Pieri, O S, Zani, L C, Domas, G G, Barbosa, C S
Format: Article
Language:English
Subjects:
Animals
Anthelmintics - therapeutic use
Brazil
Brazil - epidemiology
chemotherapy
control
Crops, Agricultural
Follow-Up Studies
Humans
Northeast
Oxamniquine - therapeutic use
Parasite Egg Count
PARASITOLOGY
Praziquantel - therapeutic use
Prevalence
Prognosis
Recurrence
Rural Health
Schistosoma mansoni - isolation & purification
schistosomiasis
Schistosomiasis mansoni - drug therapy
Schistosomiasis mansoni - epidemiology
Schistosomicides - therapeutic use
Seasons
TROPICAL MEDICINE
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Summary:A group of 52 villagers was followed-up for three years regarding Schistosoma mansoni infection. All villagers were periodically surveyed by the Kato-Katz method. In March 1997 and March 1998 the positives were treated with oxamniquine (15-20 mg/kg), and in March 1999, with praziquantel (60 mg/kg). All infection indices decreased substantially between March 1999 and March 2000: prevalence of infection (from 32.7% to 21.2%), prevalence of moderate/heavy infection (from 7.7% to 1.9%), intensity of infection (from 23.1 epg to 7.4 epg) and reinfection (from 35.7% to 14.3%). Negativation increased from 53.8 to 82.4. An optimistic prognostic is assumed in the short term for the introduction of praziquantel in the study area.
ISSN:0074-0276
1678-8060
0074-0276
1678-8060
DOI:10.1590/S0074-02762001000900025