Profound Changes in Net Energy and Nitrogen Metabolites Fluxes within the Splanchnic Area during Overfeeding of Yucatan Mini Pigs That Remain Euglycemic

A dysregulation of nutrient exchange between tissues (gut, liver, muscles, adipose) occurs during overnutrition and could induce obesity and metabolic diseases. We aimed to evaluate how, in overfed mini pigs, nutrients use and partition were regulated in the gut and liver. Net nutrients fluxes were...

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Bibliographic Details
Published in:Nutrients 2019-02, Vol.11 (2), p.434
Main Authors: Isabelle, Savary-Auzeloux, Ahmed-Ben, Mohamed, Benoit, Cohade, Dominique, Dardevet, Jérémie, David, Noureddine, Hafnaoui, Carole, Migné, Estelle, Pujos-Guillot, Didier, Rémond, Sergio, Polakof
Format: Article
Language:English
Subjects:
amino acid
Food and Nutrition
glucose
gut
Insulin resistance
lactate
Life Sciences
liver
Metabolites
minipig
nutrient flux
Nutrition
Obesity
short chain fatty acid
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Summary:A dysregulation of nutrient exchange between tissues (gut, liver, muscles, adipose) occurs during overnutrition and could induce obesity and metabolic diseases. We aimed to evaluate how, in overfed mini pigs, nutrients use and partition were regulated in the gut and liver. Net nutrients fluxes were assessed in the fed (PP) and post absorptive (PA) states at 1, 14 and 60 days of adaptation to overfeeding in five adult Yucatan female multicatheterized minipigs. Pigs PA glycaemia and PP-induced hyperglycemia remained unchanged over the experimental period, suggesting that the management of the excess of energy intake allowed the maintenance of glucose levels. This was associated with (1) an increased PA plasma insulin, (2) an increased gut lactate production (increased lactate net release +89%, 1 h PP, D1 vs. D60) probably from an increased glucose oxidation, (3) a shift in utilization of gluconeogenic precursor (lactate, propionate) in the liver, and (4) a reduced gut utilization of nitrogen moieties for energy purposes (glutamine), a nitrogen sparing effect at the whole body level (decreased plasma urea in PA (-24% D1 vs. D60) and PP states) and a specific increased level of AA involved in lipids handling and bile recycling in the gut lumen (taurine and glycine).
ISSN:2072-6643
2072-6643
DOI:10.3390/nu11020434