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Clinical relevance of aortic conduit and reservoir function
BackgroundAortic conduit and reservoir functions can be directly measured by four-dimensional flow (4D flow) cardiovascular magnetic resonance (CMR).MethodsTwenty healthy controls (10 young and 10 age-gender-matched old controls) and 20 patients with heart failure with preserved ejection fraction (H...
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creator | Assadi, Hosamadin Sawh, Chris Spohr, Hilmar Nelthorpe, Faye Nair, Sunil Hughes, Marina Ashman, David Ryding, Alisdair Matthews, Gareth Li, Rui Grafton-Clarke, Ciaran Mehmood, Zia Al-Mohammad, Abdallah Kasmai, Bahman Vassiliou, Vassilios S Garg, Pankaj |
description | BackgroundAortic conduit and reservoir functions can be directly measured by four-dimensional flow (4D flow) cardiovascular magnetic resonance (CMR).MethodsTwenty healthy controls (10 young and 10 age-gender-matched old controls) and 20 patients with heart failure with preserved ejection fraction (HFpEF) were recruited. All had 4D flow CMR. Flow was quantified at the ascending and descending aorta levels. In addition, at the ascending aorta level, we quantified systolic flow displacement (FDs) and systolic flow reversal ratio (sFRR). The aortic conduit function was defined as the relative drop in systolic flow from the ascending to the descending aorta (∆Fs). Aortic reservoir function was defined as descending aortic diastolic stroke volume (DAo SVd).ResultsBoth ∆Fs (R=0.51, p=0.001) and DAo SVd (R=−0.68, p=0.001) were significantly associated with ageing. Native T1 (R=0.51, p=0.001) and extracellular volume (R=0.51, p=0.001) showed maximum association with ∆Fs. ∆Fs significantly increased in HFpEF versus age-gender-matched controls (41±8% vs 52±12%, p=0.02). In multiple regression, only ∆Fs and DAo SVd were independent predictors of the estimated glomerular filtration rate (model R=0.77, p=0.0001). FDs was significantly associated with ∆Fs (R=0.4, p=0.01) and DAo SVd (R=−0.48, p=0.002), whereas sFRR was mainly associated with DAo SVd (R=−0.46, p=0.003).ConclusionBoth aortic conduit and reservoir function decline with age and this decline in aortic function is also independently associated with renal functional decline. Ascending aortic turbulent flow signatures are associated with loss of aortic conduit and reservoir functions. Finally, in HFpEF, aortic conduit and reservoir function demonstrate progressive decline.Trials registration numberNCT05114785. |
doi_str_mv | 10.1136/openhrt-2024-002713 |
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fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_2af050e0a0f042d88517e321806d7546</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_2af050e0a0f042d88517e321806d7546</doaj_id><sourcerecordid>3099161144</sourcerecordid><originalsourceid>FETCH-LOGICAL-b331t-69466e9ab245c3cf7634d297235fbcaa1fae1628642713147841338b6bc1eabb3</originalsourceid><addsrcrecordid>eNpdkk1r3DAQhkVpaUKaX1Aohl56cTKjkSWbHkpZ-hEI9NKehSTLiRavtJXthf77yt1tk_QkoXl4eDUzjL1GuEIkeZ32Pt7nuebARQ3AFdIzds6hoZokF88f3c_Y5TRtAQB5I6GTL9kZdSgBWnnO3m_GEIMzY5X96A8mOl-loTIpz8FVLsV-CXNlYl_qk8-HFHI1LNHNIcVX7MVgxslfns4L9uPzp--br_Xtty83m4-3tSXCuZadkNJ3xnLROHKDkiR63ilOzWCdMTgYj5K3Uqy_QKFagUStldahN9bSBbs5evtktnqfw87kXzqZoP88pHynzRp39JqbARrwYGAAwfu2bVB54tiC7FUjZHF9OLr2i9353vk4ZzM-kT6txHCv79JBl66TkkoVw7uTIaefi59mvQuT8-Nook_LpAk60XLkggr69j90m5YcS69WqswAUYhCvXkc6V-Wv0MqwPURsLvtgwFhzST1aRP0ugn6uAn0G6MPo18</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3099161144</pqid></control><display><type>article</type><title>Clinical relevance of aortic conduit and reservoir function</title><source>BMJ Open Access Journals</source><source>Open Access: PubMed Central</source><source>Publicly Available Content Database</source><creator>Assadi, Hosamadin ; Sawh, Chris ; Spohr, Hilmar ; Nelthorpe, Faye ; Nair, Sunil ; Hughes, Marina ; Ashman, David ; Ryding, Alisdair ; Matthews, Gareth ; Li, Rui ; Grafton-Clarke, Ciaran ; Mehmood, Zia ; Al-Mohammad, Abdallah ; Kasmai, Bahman ; Vassiliou, Vassilios S ; Garg, Pankaj</creator><creatorcontrib>Assadi, Hosamadin ; Sawh, Chris ; Spohr, Hilmar ; Nelthorpe, Faye ; Nair, Sunil ; Hughes, Marina ; Ashman, David ; Ryding, Alisdair ; Matthews, Gareth ; Li, Rui ; Grafton-Clarke, Ciaran ; Mehmood, Zia ; Al-Mohammad, Abdallah ; Kasmai, Bahman ; Vassiliou, Vassilios S ; Garg, Pankaj</creatorcontrib><description>BackgroundAortic conduit and reservoir functions can be directly measured by four-dimensional flow (4D flow) cardiovascular magnetic resonance (CMR).MethodsTwenty healthy controls (10 young and 10 age-gender-matched old controls) and 20 patients with heart failure with preserved ejection fraction (HFpEF) were recruited. All had 4D flow CMR. Flow was quantified at the ascending and descending aorta levels. In addition, at the ascending aorta level, we quantified systolic flow displacement (FDs) and systolic flow reversal ratio (sFRR). The aortic conduit function was defined as the relative drop in systolic flow from the ascending to the descending aorta (∆Fs). Aortic reservoir function was defined as descending aortic diastolic stroke volume (DAo SVd).ResultsBoth ∆Fs (R=0.51, p=0.001) and DAo SVd (R=−0.68, p=0.001) were significantly associated with ageing. Native T1 (R=0.51, p=0.001) and extracellular volume (R=0.51, p=0.001) showed maximum association with ∆Fs. ∆Fs significantly increased in HFpEF versus age-gender-matched controls (41±8% vs 52±12%, p=0.02). In multiple regression, only ∆Fs and DAo SVd were independent predictors of the estimated glomerular filtration rate (model R=0.77, p=0.0001). FDs was significantly associated with ∆Fs (R=0.4, p=0.01) and DAo SVd (R=−0.48, p=0.002), whereas sFRR was mainly associated with DAo SVd (R=−0.46, p=0.003).ConclusionBoth aortic conduit and reservoir function decline with age and this decline in aortic function is also independently associated with renal functional decline. Ascending aortic turbulent flow signatures are associated with loss of aortic conduit and reservoir functions. Finally, in HFpEF, aortic conduit and reservoir function demonstrate progressive decline.Trials registration numberNCT05114785.</description><identifier>ISSN: 2053-3624</identifier><identifier>ISSN: 2398-595X</identifier><identifier>EISSN: 2053-3624</identifier><identifier>DOI: 10.1136/openhrt-2024-002713</identifier><identifier>PMID: 39160086</identifier><language>eng</language><publisher>England: British Cardiovascular Society</publisher><subject>Adult ; Aged ; Aging ; Aorta - diagnostic imaging ; Aorta - physiopathology ; Aorta, Thoracic - diagnostic imaging ; Aorta, Thoracic - physiopathology ; Aortic and Vascular Disease ; aortic diseases ; Blood Flow Velocity - physiology ; Cardiology ; Cardiomyopathy ; Cardiovascular disease ; Clinical Relevance ; Contrast agents ; Coronary vessels ; Ejection fraction ; Female ; Heart failure ; Heart Failure - diagnosis ; Heart Failure - physiopathology ; Humans ; magnetic resonance imaging ; Magnetic Resonance Imaging, Cine - methods ; Male ; Middle Aged ; Original Research ; Stroke Volume - physiology ; Ventricular Function, Left - physiology ; Workloads</subject><ispartof>Open heart, 2024-08, Vol.11 (2), p.e002713</ispartof><rights>Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ.</rights><rights>2024 Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-b331t-69466e9ab245c3cf7634d297235fbcaa1fae1628642713147841338b6bc1eabb3</cites><orcidid>0000-0001-6517-8692 ; 0000-0002-5483-169X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/3099161144/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/3099161144?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,55350,75126,77660,77686</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39160086$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Assadi, Hosamadin</creatorcontrib><creatorcontrib>Sawh, Chris</creatorcontrib><creatorcontrib>Spohr, Hilmar</creatorcontrib><creatorcontrib>Nelthorpe, Faye</creatorcontrib><creatorcontrib>Nair, Sunil</creatorcontrib><creatorcontrib>Hughes, Marina</creatorcontrib><creatorcontrib>Ashman, David</creatorcontrib><creatorcontrib>Ryding, Alisdair</creatorcontrib><creatorcontrib>Matthews, Gareth</creatorcontrib><creatorcontrib>Li, Rui</creatorcontrib><creatorcontrib>Grafton-Clarke, Ciaran</creatorcontrib><creatorcontrib>Mehmood, Zia</creatorcontrib><creatorcontrib>Al-Mohammad, Abdallah</creatorcontrib><creatorcontrib>Kasmai, Bahman</creatorcontrib><creatorcontrib>Vassiliou, Vassilios S</creatorcontrib><creatorcontrib>Garg, Pankaj</creatorcontrib><title>Clinical relevance of aortic conduit and reservoir function</title><title>Open heart</title><addtitle>Open Heart</addtitle><addtitle>Open Heart</addtitle><description>BackgroundAortic conduit and reservoir functions can be directly measured by four-dimensional flow (4D flow) cardiovascular magnetic resonance (CMR).MethodsTwenty healthy controls (10 young and 10 age-gender-matched old controls) and 20 patients with heart failure with preserved ejection fraction (HFpEF) were recruited. All had 4D flow CMR. Flow was quantified at the ascending and descending aorta levels. In addition, at the ascending aorta level, we quantified systolic flow displacement (FDs) and systolic flow reversal ratio (sFRR). The aortic conduit function was defined as the relative drop in systolic flow from the ascending to the descending aorta (∆Fs). Aortic reservoir function was defined as descending aortic diastolic stroke volume (DAo SVd).ResultsBoth ∆Fs (R=0.51, p=0.001) and DAo SVd (R=−0.68, p=0.001) were significantly associated with ageing. Native T1 (R=0.51, p=0.001) and extracellular volume (R=0.51, p=0.001) showed maximum association with ∆Fs. ∆Fs significantly increased in HFpEF versus age-gender-matched controls (41±8% vs 52±12%, p=0.02). In multiple regression, only ∆Fs and DAo SVd were independent predictors of the estimated glomerular filtration rate (model R=0.77, p=0.0001). FDs was significantly associated with ∆Fs (R=0.4, p=0.01) and DAo SVd (R=−0.48, p=0.002), whereas sFRR was mainly associated with DAo SVd (R=−0.46, p=0.003).ConclusionBoth aortic conduit and reservoir function decline with age and this decline in aortic function is also independently associated with renal functional decline. Ascending aortic turbulent flow signatures are associated with loss of aortic conduit and reservoir functions. Finally, in HFpEF, aortic conduit and reservoir function demonstrate progressive decline.Trials registration numberNCT05114785.</description><subject>Adult</subject><subject>Aged</subject><subject>Aging</subject><subject>Aorta - diagnostic imaging</subject><subject>Aorta - physiopathology</subject><subject>Aorta, Thoracic - diagnostic imaging</subject><subject>Aorta, Thoracic - physiopathology</subject><subject>Aortic and Vascular Disease</subject><subject>aortic diseases</subject><subject>Blood Flow Velocity - physiology</subject><subject>Cardiology</subject><subject>Cardiomyopathy</subject><subject>Cardiovascular disease</subject><subject>Clinical Relevance</subject><subject>Contrast agents</subject><subject>Coronary vessels</subject><subject>Ejection fraction</subject><subject>Female</subject><subject>Heart failure</subject><subject>Heart Failure - diagnosis</subject><subject>Heart Failure - physiopathology</subject><subject>Humans</subject><subject>magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging, Cine - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original Research</subject><subject>Stroke Volume - physiology</subject><subject>Ventricular Function, Left - physiology</subject><subject>Workloads</subject><issn>2053-3624</issn><issn>2398-595X</issn><issn>2053-3624</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>9YT</sourceid><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdkk1r3DAQhkVpaUKaX1Aohl56cTKjkSWbHkpZ-hEI9NKehSTLiRavtJXthf77yt1tk_QkoXl4eDUzjL1GuEIkeZ32Pt7nuebARQ3AFdIzds6hoZokF88f3c_Y5TRtAQB5I6GTL9kZdSgBWnnO3m_GEIMzY5X96A8mOl-loTIpz8FVLsV-CXNlYl_qk8-HFHI1LNHNIcVX7MVgxslfns4L9uPzp--br_Xtty83m4-3tSXCuZadkNJ3xnLROHKDkiR63ilOzWCdMTgYj5K3Uqy_QKFagUStldahN9bSBbs5evtktnqfw87kXzqZoP88pHynzRp39JqbARrwYGAAwfu2bVB54tiC7FUjZHF9OLr2i9353vk4ZzM-kT6txHCv79JBl66TkkoVw7uTIaefi59mvQuT8-Nook_LpAk60XLkggr69j90m5YcS69WqswAUYhCvXkc6V-Wv0MqwPURsLvtgwFhzST1aRP0ugn6uAn0G6MPo18</recordid><startdate>20240819</startdate><enddate>20240819</enddate><creator>Assadi, Hosamadin</creator><creator>Sawh, Chris</creator><creator>Spohr, Hilmar</creator><creator>Nelthorpe, Faye</creator><creator>Nair, Sunil</creator><creator>Hughes, Marina</creator><creator>Ashman, David</creator><creator>Ryding, Alisdair</creator><creator>Matthews, Gareth</creator><creator>Li, Rui</creator><creator>Grafton-Clarke, Ciaran</creator><creator>Mehmood, Zia</creator><creator>Al-Mohammad, Abdallah</creator><creator>Kasmai, Bahman</creator><creator>Vassiliou, Vassilios S</creator><creator>Garg, Pankaj</creator><general>British Cardiovascular Society</general><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><scope>9YT</scope><scope>ACMMV</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-6517-8692</orcidid><orcidid>https://orcid.org/0000-0002-5483-169X</orcidid></search><sort><creationdate>20240819</creationdate><title>Clinical relevance of aortic conduit and reservoir function</title><author>Assadi, Hosamadin ; Sawh, Chris ; Spohr, Hilmar ; Nelthorpe, Faye ; Nair, Sunil ; Hughes, Marina ; Ashman, David ; Ryding, Alisdair ; Matthews, Gareth ; Li, Rui ; Grafton-Clarke, Ciaran ; Mehmood, Zia ; Al-Mohammad, Abdallah ; Kasmai, Bahman ; Vassiliou, Vassilios S ; Garg, Pankaj</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b331t-69466e9ab245c3cf7634d297235fbcaa1fae1628642713147841338b6bc1eabb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aging</topic><topic>Aorta - diagnostic imaging</topic><topic>Aorta - physiopathology</topic><topic>Aorta, Thoracic - diagnostic imaging</topic><topic>Aorta, Thoracic - physiopathology</topic><topic>Aortic and Vascular Disease</topic><topic>aortic diseases</topic><topic>Blood Flow Velocity - physiology</topic><topic>Cardiology</topic><topic>Cardiomyopathy</topic><topic>Cardiovascular disease</topic><topic>Clinical Relevance</topic><topic>Contrast agents</topic><topic>Coronary vessels</topic><topic>Ejection fraction</topic><topic>Female</topic><topic>Heart failure</topic><topic>Heart Failure - diagnosis</topic><topic>Heart Failure - physiopathology</topic><topic>Humans</topic><topic>magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging, Cine - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original Research</topic><topic>Stroke Volume - physiology</topic><topic>Ventricular Function, Left - physiology</topic><topic>Workloads</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Assadi, Hosamadin</creatorcontrib><creatorcontrib>Sawh, Chris</creatorcontrib><creatorcontrib>Spohr, Hilmar</creatorcontrib><creatorcontrib>Nelthorpe, Faye</creatorcontrib><creatorcontrib>Nair, Sunil</creatorcontrib><creatorcontrib>Hughes, Marina</creatorcontrib><creatorcontrib>Ashman, David</creatorcontrib><creatorcontrib>Ryding, Alisdair</creatorcontrib><creatorcontrib>Matthews, Gareth</creatorcontrib><creatorcontrib>Li, Rui</creatorcontrib><creatorcontrib>Grafton-Clarke, Ciaran</creatorcontrib><creatorcontrib>Mehmood, Zia</creatorcontrib><creatorcontrib>Al-Mohammad, Abdallah</creatorcontrib><creatorcontrib>Kasmai, Bahman</creatorcontrib><creatorcontrib>Vassiliou, Vassilios S</creatorcontrib><creatorcontrib>Garg, Pankaj</creatorcontrib><collection>BMJ Open Access Journals</collection><collection>BMJ Journals:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Open heart</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Assadi, Hosamadin</au><au>Sawh, Chris</au><au>Spohr, Hilmar</au><au>Nelthorpe, Faye</au><au>Nair, Sunil</au><au>Hughes, Marina</au><au>Ashman, David</au><au>Ryding, Alisdair</au><au>Matthews, Gareth</au><au>Li, Rui</au><au>Grafton-Clarke, Ciaran</au><au>Mehmood, Zia</au><au>Al-Mohammad, Abdallah</au><au>Kasmai, Bahman</au><au>Vassiliou, Vassilios S</au><au>Garg, Pankaj</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical relevance of aortic conduit and reservoir function</atitle><jtitle>Open heart</jtitle><stitle>Open Heart</stitle><addtitle>Open Heart</addtitle><date>2024-08-19</date><risdate>2024</risdate><volume>11</volume><issue>2</issue><spage>e002713</spage><pages>e002713-</pages><issn>2053-3624</issn><issn>2398-595X</issn><eissn>2053-3624</eissn><abstract>BackgroundAortic conduit and reservoir functions can be directly measured by four-dimensional flow (4D flow) cardiovascular magnetic resonance (CMR).MethodsTwenty healthy controls (10 young and 10 age-gender-matched old controls) and 20 patients with heart failure with preserved ejection fraction (HFpEF) were recruited. All had 4D flow CMR. Flow was quantified at the ascending and descending aorta levels. In addition, at the ascending aorta level, we quantified systolic flow displacement (FDs) and systolic flow reversal ratio (sFRR). The aortic conduit function was defined as the relative drop in systolic flow from the ascending to the descending aorta (∆Fs). Aortic reservoir function was defined as descending aortic diastolic stroke volume (DAo SVd).ResultsBoth ∆Fs (R=0.51, p=0.001) and DAo SVd (R=−0.68, p=0.001) were significantly associated with ageing. Native T1 (R=0.51, p=0.001) and extracellular volume (R=0.51, p=0.001) showed maximum association with ∆Fs. ∆Fs significantly increased in HFpEF versus age-gender-matched controls (41±8% vs 52±12%, p=0.02). In multiple regression, only ∆Fs and DAo SVd were independent predictors of the estimated glomerular filtration rate (model R=0.77, p=0.0001). FDs was significantly associated with ∆Fs (R=0.4, p=0.01) and DAo SVd (R=−0.48, p=0.002), whereas sFRR was mainly associated with DAo SVd (R=−0.46, p=0.003).ConclusionBoth aortic conduit and reservoir function decline with age and this decline in aortic function is also independently associated with renal functional decline. Ascending aortic turbulent flow signatures are associated with loss of aortic conduit and reservoir functions. Finally, in HFpEF, aortic conduit and reservoir function demonstrate progressive decline.Trials registration numberNCT05114785.</abstract><cop>England</cop><pub>British Cardiovascular Society</pub><pmid>39160086</pmid><doi>10.1136/openhrt-2024-002713</doi><orcidid>https://orcid.org/0000-0001-6517-8692</orcidid><orcidid>https://orcid.org/0000-0002-5483-169X</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Adult Aged Aging Aorta - diagnostic imaging Aorta - physiopathology Aorta, Thoracic - diagnostic imaging Aorta, Thoracic - physiopathology Aortic and Vascular Disease aortic diseases Blood Flow Velocity - physiology Cardiology Cardiomyopathy Cardiovascular disease Clinical Relevance Contrast agents Coronary vessels Ejection fraction Female Heart failure Heart Failure - diagnosis Heart Failure - physiopathology Humans magnetic resonance imaging Magnetic Resonance Imaging, Cine - methods Male Middle Aged Original Research Stroke Volume - physiology Ventricular Function, Left - physiology Workloads |
title | Clinical relevance of aortic conduit and reservoir function |
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