Unveiling caspase-2 regulation by non-coding RNAs

Non-coding RNAs (ncRNAs) are a group of RNA molecules, such as small nucleolar RNAs, circular RNAs (circRNAs), microRNAs (miRNAs) and long-noncoding RNAs (ncRNAs), that do not encode proteins. Although their biofunctions are not well-understood, many regulatory ncRNAs appear to be highly involved in...

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Bibliographic Details
Published in:Cell death & disease 2022-09, Vol.13 (9), p.834-10, Article 834
Main Authors: Zhao, Yun, Dhani, Shanel, Zhivotovsky, Boris
Format: Article
Language:English
Subjects:
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Animals
Antibodies
Apoptosis
Biochemistry
Biomedical and Life Sciences
Caspase 2 - genetics
Caspase-2
Cell Biology
Cell Culture
Cell death
Cell differentiation
Humans
Immunology
Life Sciences
Mammals - genetics
Medicin och hälsovetenskap
MicroRNAs - genetics
MicroRNAs - metabolism
miRNA
Non-coding RNA
Nucleoli
Review
Review Article
RNA, Circular
RNA, Long Noncoding - genetics
RNA, Untranslated - genetics
RNA, Untranslated - metabolism
snoRNA
Tumor suppressor genes
Tumorigenesis
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Summary:Non-coding RNAs (ncRNAs) are a group of RNA molecules, such as small nucleolar RNAs, circular RNAs (circRNAs), microRNAs (miRNAs) and long-noncoding RNAs (ncRNAs), that do not encode proteins. Although their biofunctions are not well-understood, many regulatory ncRNAs appear to be highly involved in regulating the transcription and translation of several genes that have essential biological roles including cell differentiation, cell death, metabolism, tumorigenesis and so on. A growing number of studies have revealed the associations between dysregulated ncRNAs and caspases involved in cell death in numerous human diseases. As one of the initiator and executor caspases, caspase-2 is the most evolutionally conserved caspase in mammals, exerting both apoptotic and non-apoptotic functions. A great deal of studies has shown the involvement of caspase-2 as a tumor suppressor in multiple oncogene-driven cancers, and yet a comprehensive understanding of its biological roles remains largely unknown. In this review, we highlight a compilation of studies focused on the interaction between caspase-2 and miRNAs/lncRNAs in the context of different diseases in order to deepen our knowledge on the regulatory biofunctions of caspase-2 and, furthermore, provide more insight into understanding the role that ncRNAs/caspase-2 axis plays in the development of human diseases.
ISSN:2041-4889
2041-4889
DOI:10.1038/s41419-022-05270-1