Synaptic GluN2A-Containing NMDA Receptors: From Physiology to Pathological Synaptic Plasticity

N-Methyl-d-Aspartate Receptors (NMDARs) are ionotropic glutamate-gated receptors. NMDARs are tetramers composed by several homologous subunits of GluN1-, GluN2-, or GluN3-type, leading to the existence in the central nervous system of a high variety of receptor subtypes with different pharmacologica...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-02, Vol.21 (4), p.1538
Main Authors: Franchini, Luca, Carrano, Nicolò, Di Luca, Monica, Gardoni, Fabrizio
Format: Article
Language:English
Subjects:
Binding sites
brain disorders
Central nervous system
Chemical compounds
dendritic spines
glutamate
Glutamic acid receptors (ionotropic)
Homology
Mutation
N-Methyl-D-aspartic acid receptors
Neurological disorders
nmda receptors
Pharmaceuticals
Phosphorylation
Physiology
Proteins
Regulatory subunits
Review
Subunit structure
Synaptic plasticity
Synaptogenesis
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Summary:N-Methyl-d-Aspartate Receptors (NMDARs) are ionotropic glutamate-gated receptors. NMDARs are tetramers composed by several homologous subunits of GluN1-, GluN2-, or GluN3-type, leading to the existence in the central nervous system of a high variety of receptor subtypes with different pharmacological and signaling properties. NMDAR subunit composition is strictly regulated during development and by activity-dependent synaptic plasticity. Given the differences between GluN2 regulatory subunits of NMDAR in several functions, here we will focus on the synaptic pool of NMDARs containing the GluN2A subunit, addressing its role in both physiology and pathological synaptic plasticity as well as the contribution in these events of different types of GluN2A-interacting proteins.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21041538