P53 in lung vascular barrier dysfunction

Endothelial barrier dysfunction is the hallmark of inflammatory lung disease, including Acute Lung Injury and Acute Respiratory Distress Syndrome. The purpose of the present editorial is to emphasize on recent advances in the corresponding field, as it relates to P53. This tumor suppressor protein h...

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Bibliographic Details
Published in:Vascular biology 2020-05, Vol.2 (1), p.E1-E2
Main Author: Barabutis, Nektarios
Format: Article
Language:English
Subjects:
acute lung injury
acute respiratory distress syndrome
growth hormone
hsp90
inflammation
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Summary:Endothelial barrier dysfunction is the hallmark of inflammatory lung disease, including Acute Lung Injury and Acute Respiratory Distress Syndrome. The purpose of the present editorial is to emphasize on recent advances in the corresponding field, as it relates to P53. This tumor suppressor protein has been shown to enhance the vascular barrier integrity via distinct molecular pathways. Further, it mediates the beneficial effects of heat shock protein 90 inhibitors and growth hormone releasing hormone antagonists in the lung microvasculature.
ISSN:2516-5658
2516-5658
DOI:10.1530/VB-20-0004