Cardiac Troponin I and Electrocardiographic Evaluation in Hospitalized Cats with Systemic Inflammatory Response Syndrome

• Published in: Veterinary sciences 2023-09, Vol.10 (9), p.570
• Main Authors: Pugliese, Michela, Napoli, Ettore, La Maestra, Rocky, Or, Mehmet Erman, Bilgiç, Bengü, Previti, Annalisa, Biondi, Vito, Passantino, Annamaria
• Format: Article
• Language: English
• Subjects: Biochemistry; Blood levels; Blood pressure; Body temperature; Bradycardia; Cardiac arrhythmia; cardiac damage; Cardiology; cat; Cell number; cTnI; Development and progression; Diagnosis; Echocardiography; Emergency medical care; Ethylenediaminetetraacetic acid; Heart beat; Heart rate; Inflammation; Laboratory animals; Leukocytes; Leukocytes (neutrophilic); Measurement; Medical prognosis; Morphology; Mortality; Multiple organ dysfunction syndrome; Nervous system diseases; Neurological diseases; Respiration; Sepsis; Sinuses; SIRS; Systemic inflammatory response syndrome; Tachycardia; Thyroxine; Troponin I; Urinalysis; Ventricle; Veterinary medicine
• ISSN: 2306-7381; 2306-7381
• DOI: 10.3390/vetsci10090570

Several studies conducted on humans demonstrate the increase in cardiac troponins and the onset of arrhythmias in the course of systemic inflammatory response syndrome (SIRS). The aim of the current study was to assess the blood concentration of cardiac troponin I (cTnI) and electrocardiographic findings in SIRS-affected cats. Seventeen shorthair cats hospitalized with SIRS were enrolled (Group 1). SIRS diagnosis was performed based on the detection of at least two of the four criteria such as abnormal body temperature, abnormal heart rate (i.e., tachycardia or bradycardia), abnormal respiratory rate (i.e., tachypnea or bradypnea), and alterations of white blood cell number (i.e., leukocytes or band neutrophils). Ten cats screened for elective surgery such as neutering or dental procedures were evaluated as a control population (Group 2). They were considered healthy based on history, physical examination, hematological and biochemical profile, urinalysis, coprological exam, thyroxine assay, blood pressure measurement, and echocardiography. A physical examination, complete blood cell count, biochemistry test (including an electrolyte panel), electrocardiographic examination, and cTnI assay were carried out in each cat enrolled. Traumatic events, gastrointestinal, neoplastic, respiratory, and neurological disorders were identified as causes of SIRS in Group 1. In Group 1, a significantly higher concentration of cTnI than that in Group 2 was recorded (p = 0.004). In 37.5% of cats with SIRS, ventricular premature complexes occurring in couplets with multiform configuration were detected. Similarly, to humans, data herein reported would indicate possible cardiac damage present in cats with SIRS diagnosis.