Higher body mass index indicated better overall survival in pancreatic ductal adenocarcinoma patients: a real-world study of 2010 patients

The association between body mass index (BMI) and the overall survival (OS) of pancreatic ductal adenocarcinoma (PDAC) patients remains controversial and unclear, METHOD: A total of 2010 patients from a high-volume center were enrolled in the study. The OS of PDAC patients was evaluated based on res...

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Bibliographic Details
Published in:BMC cancer 2021-12, Vol.21 (1), p.1318-1318, Article 1318
Main Authors: Fu, Ningzhen, Jiang, Yu, Qin, Kai, Chen, Hao, Deng, Xiaxing, Shen, Baiyong
Format: Article
Language:English
Subjects:
Adenocarcinoma
Aged
Analysis
Antineoplastic Agents - therapeutic use
Body Mass Index
Body mass index (BMI). Pancreatic ductal adenocarcinoma (PDAC). Overall survival (OS). Restricted cubic spline (RCS). Chemotherapy
Carcinoma, Pancreatic Ductal - epidemiology
Carcinoma, Pancreatic Ductal - mortality
Care and treatment
Chemotherapy
Female
Humans
Male
Medical prognosis
Metastasis
Middle Aged
Overweight
Overweight - epidemiology
Pancreas
Pancreatic cancer
Pancreatic Neoplasms
Pancreatic Neoplasms - epidemiology
Pancreatic Neoplasms - mortality
Prognosis
Retrospective Studies
Statistics
Survival
Survival analysis
Thinness - epidemiology
Variables
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Summary:The association between body mass index (BMI) and the overall survival (OS) of pancreatic ductal adenocarcinoma (PDAC) patients remains controversial and unclear, METHOD: A total of 2010 patients from a high-volume center were enrolled in the study. The OS of PDAC patients was evaluated based on restricted cubic spline (RCS), propensity score (PS) and multivariable risk adjustment analyses. BMI was linearly related to the OS (total P = 0.004, nonlinear P = 0.124). BMI was analyzed as categorical data based on X-tile software-defined cutoffs and World Health Organization (WHO)-recommended cutoffs. Adjusted with confounding covariates, higher BMI manifested as a positive prognostic predictor. Furthermore, BMI was proven to be associated with the OS in the PS analysis. (Underweight vs. Normal P = 0.003, Overweight vs. Normal P = 0.019; Underweight vs. Normal P 
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-021-09056-0