Two New Piperazine-Triones from a Marine-Derived Streptomycetes sp. Strain SMS636

Two new piperazine-triones lansai E and F ( , ), together with four known secondary metabolites lansai D ( ), 1- -methyl-( )-albonoursin ( ), imidazo[4,5- ]-1,2,4-triazine ( ), and streptonigrin ( ) were isolated from a deep-sea-derived sp. strain SMS636. The structures of the isolated compounds wer...

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Bibliographic Details
Published in:Marine drugs 2019-03, Vol.17 (3), p.186
Main Authors: Xu, Xiuli, Han, Jiahui, Lin, Rui, Polyak, Steven W, Song, Fuhang
Format: Article
Language:English
Subjects:
Albonoursin
antibacterial
Antibacterial activity
Antibiotics
Carbon
Deep sea
Deep water
Drug resistance
E coli
Gram-positive bacteria
Hydrocarbons
marine-derived Streptomycetes
Metabolites
Methicillin
Microbiological strains
Minimum inhibitory concentration
MRSA
Natural products
NMR
Nuclear magnetic resonance
Piperazine
piperazine-trione
Secondary metabolites
Solvents
Spectrum analysis
Staphylococcus aureus
Streptomycetes
Streptonigrin
Triazine
Two dimensional analysis
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Summary:Two new piperazine-triones lansai E and F ( , ), together with four known secondary metabolites lansai D ( ), 1- -methyl-( )-albonoursin ( ), imidazo[4,5- ]-1,2,4-triazine ( ), and streptonigrin ( ) were isolated from a deep-sea-derived sp. strain SMS636. The structures of the isolated compounds were confirmed by comprehensive spectroscopic analysis, including HRESIMS, 1D and 2D NMR. Compound exhibited moderate antibacterial activities against and methicillin resistant (MRSA) with Minimum Inhibitory Concentration (MIC) values of 12.5 and 25 μg/mL, respectively. Compound displayed significant antibacterial activities against , MRSA and Bacillus Calmette-Guérin (BCG) with MIC values of 0.78, 0.78 and 1.25 μg/mL, respectively.
ISSN:1660-3397
1660-3397
DOI:10.3390/md17030186