Longitudinal association of epicardial and thoracic adipose tissues with coronary and cardiac characteristics in psoriasis

• Published in: Heliyon 2023-10, Vol.9 (10), p.e20732-e20732, Article e20732
• Main Authors: O'Hagan, Ross, Hsu, Li-Yueh, Li, Haiou, Hong, Christin G., Parel, Philip M., Berg, Alexander R., Manyak, Grigory A., Bui, Vy, Patel, Nidhi H., Florida, Elizabeth M., Teague, Heather L., Playford, Martin P., Zhou, Wunan, Dey, Damini, Chen, Marcus Y., Mehta, Nehal N., Sorokin, Alexander V.
• Format: Article
• Language: English
• Subjects: Cardiovascular disease; Computed tomography; Epicardial fat tissue; Prevention; Psoriasis
• ISSN: 2405-8440; 2405-8440
• DOI: 10.1016/j.heliyon.2023.e20732

s: Psoriasis is a disease of systemic inflammation associated with increased cardiometabolic risk. Epicardial adipose tissue (EAT) and thoracic adipose tissue (TAT) are contributing factors for atherosclerosis and cardiac dysfunction. We strove to assess the longitudinal impact of the EAT and TAT on coronary and cardiac characteristics in psoriasis. The study consisted of 301 patients with baseline coronary computed tomography angiography (CTA), of which 139 had four-year follow up scans. EAT and TAT volumes from non-contrast computed tomography scans were quantified by an automated segmentation framework. Coronary plaque characteristics and left ventricular (LV) mass were quantified by CTA. When stratified by baseline EAT and TAT volume quartiles, a stepwise significant increase in cardiometabolic parameters was observed. EAT and TAT volumes associated with fibro-fatty burden (FFB) (TAT: ρ = 0.394, P