Longitudinal association of epicardial and thoracic adipose tissues with coronary and cardiac characteristics in psoriasis

s: Psoriasis is a disease of systemic inflammation associated with increased cardiometabolic risk. Epicardial adipose tissue (EAT) and thoracic adipose tissue (TAT) are contributing factors for atherosclerosis and cardiac dysfunction. We strove to assess the longitudinal impact of the EAT and TAT on...

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Published in:Heliyon 2023-10, Vol.9 (10), p.e20732-e20732, Article e20732
Main Authors: O'Hagan, Ross, Hsu, Li-Yueh, Li, Haiou, Hong, Christin G., Parel, Philip M., Berg, Alexander R., Manyak, Grigory A., Bui, Vy, Patel, Nidhi H., Florida, Elizabeth M., Teague, Heather L., Playford, Martin P., Zhou, Wunan, Dey, Damini, Chen, Marcus Y., Mehta, Nehal N., Sorokin, Alexander V.
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Language:English
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Cardiovascular disease
Computed tomography
Epicardial fat tissue
Prevention
Psoriasis
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creator O'Hagan, Ross
Hsu, Li-Yueh
Li, Haiou
Hong, Christin G.
Parel, Philip M.
Berg, Alexander R.
Manyak, Grigory A.
Bui, Vy
Patel, Nidhi H.
Florida, Elizabeth M.
Teague, Heather L.
Playford, Martin P.
Zhou, Wunan
Dey, Damini
Chen, Marcus Y.
Mehta, Nehal N.
Sorokin, Alexander V.
description s: Psoriasis is a disease of systemic inflammation associated with increased cardiometabolic risk. Epicardial adipose tissue (EAT) and thoracic adipose tissue (TAT) are contributing factors for atherosclerosis and cardiac dysfunction. We strove to assess the longitudinal impact of the EAT and TAT on coronary and cardiac characteristics in psoriasis. The study consisted of 301 patients with baseline coronary computed tomography angiography (CTA), of which 139 had four-year follow up scans. EAT and TAT volumes from non-contrast computed tomography scans were quantified by an automated segmentation framework. Coronary plaque characteristics and left ventricular (LV) mass were quantified by CTA. When stratified by baseline EAT and TAT volume quartiles, a stepwise significant increase in cardiometabolic parameters was observed. EAT and TAT volumes associated with fibro-fatty burden (FFB) (TAT: ρ = 0.394, P 
doi_str_mv 10.1016/j.heliyon.2023.e20732
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Epicardial adipose tissue (EAT) and thoracic adipose tissue (TAT) are contributing factors for atherosclerosis and cardiac dysfunction. We strove to assess the longitudinal impact of the EAT and TAT on coronary and cardiac characteristics in psoriasis. The study consisted of 301 patients with baseline coronary computed tomography angiography (CTA), of which 139 had four-year follow up scans. EAT and TAT volumes from non-contrast computed tomography scans were quantified by an automated segmentation framework. Coronary plaque characteristics and left ventricular (LV) mass were quantified by CTA. When stratified by baseline EAT and TAT volume quartiles, a stepwise significant increase in cardiometabolic parameters was observed. EAT and TAT volumes associated with fibro-fatty burden (FFB) (TAT: ρ = 0.394, P &lt; 0.001; EAT: ρ = 0.459, P &lt; 0.001) in adjusted models. Only EAT had a significant four-year time-dependent association with FFB in fully adjusted models (β = 0.307 P = 0.003), whereas only TAT volume associated with myocardial injury in fully adjusted models (TAT: OR = 1.57 95 % CI = (1.00–2.60); EAT: OR = 1.46 95 % CI = (0.91–2.45). Higher quartiles of EAT and TAT had increased LV mass and developed strong correlation (TAT: ρ = 0.370, P &lt; 0.001; EAT: ρ = 0.512, P &lt; 0.001). Our study is the first to explore how both EAT and TAT volumes associate with increased cardiometabolic risk profile in an inflamed psoriasis cohorts and highlight the need for further studies on its use as a potential prognostic tool for high-risk coronary plaques and cardiac dysfunction. 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Epicardial adipose tissue (EAT) and thoracic adipose tissue (TAT) are contributing factors for atherosclerosis and cardiac dysfunction. We strove to assess the longitudinal impact of the EAT and TAT on coronary and cardiac characteristics in psoriasis. The study consisted of 301 patients with baseline coronary computed tomography angiography (CTA), of which 139 had four-year follow up scans. EAT and TAT volumes from non-contrast computed tomography scans were quantified by an automated segmentation framework. Coronary plaque characteristics and left ventricular (LV) mass were quantified by CTA. When stratified by baseline EAT and TAT volume quartiles, a stepwise significant increase in cardiometabolic parameters was observed. EAT and TAT volumes associated with fibro-fatty burden (FFB) (TAT: ρ = 0.394, P &lt; 0.001; EAT: ρ = 0.459, P &lt; 0.001) in adjusted models. Only EAT had a significant four-year time-dependent association with FFB in fully adjusted models (β = 0.307 P = 0.003), whereas only TAT volume associated with myocardial injury in fully adjusted models (TAT: OR = 1.57 95 % CI = (1.00–2.60); EAT: OR = 1.46 95 % CI = (0.91–2.45). Higher quartiles of EAT and TAT had increased LV mass and developed strong correlation (TAT: ρ = 0.370, P &lt; 0.001; EAT: ρ = 0.512, P &lt; 0.001). Our study is the first to explore how both EAT and TAT volumes associate with increased cardiometabolic risk profile in an inflamed psoriasis cohorts and highlight the need for further studies on its use as a potential prognostic tool for high-risk coronary plaques and cardiac dysfunction. 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subjects Cardiovascular disease
Computed tomography
Epicardial fat tissue
Prevention
Psoriasis
title Longitudinal association of epicardial and thoracic adipose tissues with coronary and cardiac characteristics in psoriasis
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