Does oscillation size matter? Impact of added resistance on the cerebral pressure‐flow Relationship in females and males

Sinusoidal squat‐stand maneuvers (SSM) without resistance have been shown to produce ~30–50 mmHg swings in mean arterial pressure which are largely buffered in the brain via dynamic cerebral autoregulation (dCA). This study aimed to further elucidate how this regulatory mechanism is affected during...

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Bibliographic Details
Published in:Physiological reports 2022-05, Vol.10 (10), p.e15278-n/a
Main Authors: Newel, Kailey T., Burma, Joel S., Carere, Joseph, Kennedy, Courtney M., Smirl, Jonathan D.
Format: Article
Language:English
Subjects:
Arteries
Blood Flow Velocity
Blood pressure
Blood Pressure - physiology
Body mass index
Carbon dioxide
cerebral blood flow regulation
Cerebrovascular Circulation - physiology
Data collection
Doppler effect
doppler ultrasound
dynamic cerebral autoregulation
Female
Females
Gender
Heart
Homeostasis - physiology
Humans
Laboratories
Male
Males
Middle Cerebral Artery - physiology
Original
Physiology
resistance exercise
squat‐stand maneuvers
Ultrasonography, Doppler, Transcranial
Ultrasound
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Summary:Sinusoidal squat‐stand maneuvers (SSM) without resistance have been shown to produce ~30–50 mmHg swings in mean arterial pressure which are largely buffered in the brain via dynamic cerebral autoregulation (dCA). This study aimed to further elucidate how this regulatory mechanism is affected during SSM with added resistance (~20% bodyweight). Twenty‐five participants (sex/gender: 13 females/12 males) completed two bouts of 5‐min SSM for both bodyweight and resistance conditions (10% bodyweight in each arm) at frequencies of 0.05 Hz (20‐s squat/stand cycles) and 0.10 Hz (10‐s squat/stand cycles). Middle and posterior cerebral artery (MCA/PCA) cerebral blood velocities were indexed with transcranial Doppler ultrasound. Beat‐to‐beat blood pressure (BP) was quantified via finger photoplesmography. Transfer function analysis was employed to quantify dCA in both cerebral arteries across the cardiac cycle (diastole, mean, and systole). Two‐by‐two Analysis of Variance with generalized eta squared effect sizes were utilized to determine differences between resistance vs. bodyweight squats and between sexes/genders. Absolute mean and diastolic BP were elevated during the resistance squats (p 
ISSN:2051-817X
2051-817X
DOI:10.14814/phy2.15278