Immune Responses to Invasive Group B Streptococcal Disease in Adults

Immunization of nonpregnant adults could help prevent invasive group B Streptococcus (GBS) infections, but adult immune responses have not been investigated. We defined capsular polysaccharide (CPS) and pilus island (PI) surface antigen distribution and expression and immune responses to GBS infecti...

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Bibliographic Details
Published in:Emerging infectious diseases 2016-11, Vol.22 (11), p.1877-1883
Main Authors: Edwards, Morven S, Rench, Marcia A, Rinaudo, C Daniela, Fabbrini, Monica, Tuscano, Giovanna, Buffi, Giada, Bartolini, Erika, Bonacci, Stefano, Baker, Carol J, Margarit, Immaculada
Format: Article
Language:English
Subjects:
Adult
adult invasive infection
Aged
Aged, 80 and over
Antibodies, Bacterial - blood
Antibodies, Bacterial - immunology
Antibody Specificity - immunology
Bacteremia
bacteria
capsular polysaccharide
Development and progression
Female
group B Streptococcus
Humans
Immune response
Immunoglobulin G - blood
Immunoglobulin G - immunology
Male
Middle Aged
Molecular Typing
pilus island
Polysaccharides, Bacterial - immunology
Serotyping
Streptococcal infections
Streptococcal Infections - diagnosis
Streptococcal Infections - immunology
Streptococcal Infections - microbiology
Streptococcus agalactiae - classification
Streptococcus agalactiae - genetics
Streptococcus agalactiae - immunology
Streptococcus agalactiae - isolation & purification
Testing
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Summary:Immunization of nonpregnant adults could help prevent invasive group B Streptococcus (GBS) infections, but adult immune responses have not been investigated. We defined capsular polysaccharide (CPS) and pilus island (PI) surface antigen distribution and expression and immune responses to GBS infection in nonpregnant adults. Prospective surveillance from 7 hospitals in Houston, Texas, USA, identified 102 adults with GBS bacteremia; 43% had skin/soft tissue infection, 16% bacteremia without focus, and 12% osteomyelitis. CPS-specific IgG was determined by ELISA and pilus-specific IgG by multiplex immunoassay. CPS types were Ia (24.5%), Ib (12.7%), II (9.8%), III (16.7%), IV (13.7%), and V (12.7%); 9.8% were nontypeable by serologic methods. Pili, expressed by 89%, were most often PI-2a. CPS and pilus-specific IgG increased during convalescence among patients with strains expressing CPS or PI. All GBS expressed CPS or PI; 79% expressed both. Increased antibodies to CPS and PI during recovery suggests that GBS bacteremia in adults is potentially vaccine preventable.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2211.160914