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Synthesis of a Functionalized Benzofuran as a Synthon for Salvianolic Acid C Analogues as Potential LDL Antioxidants

A palladium mediated synthesis of a common synthon for the syntheses of antioxidant analogues of naturally occurring salvianolic acids is presented. The synthetic route may be used to obtain analogues with a balanced lipophilicity/hydrophilicity which may result in potentially interesting LDL antiox...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2015-05, Vol.20 (5), p.8654-8665
Main Authors: López-Frías, Gabriela, Camacho-Dávila, Alejandro A, Chávez-Flores, David, Zaragoza-Galán, Gerardo, Ramos-Sánchez, Víctor H
Format: Article
Language:English
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Summary:A palladium mediated synthesis of a common synthon for the syntheses of antioxidant analogues of naturally occurring salvianolic acids is presented. The synthetic route may be used to obtain analogues with a balanced lipophilicity/hydrophilicity which may result in potentially interesting LDL antioxidants for the prevention of cardiovascular diseases.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules20058654