Intra-operative red blood cell transfusion and mortality after cardiac surgery

Anemia in cardiac surgery patients has been associated with poor outcomes. Transfusion of red blood cells during surgery is common practice for perioperative anemia, but may come with risks. Little is known about the association between intra-operative transfusion and mortality in patients undergoin...

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Bibliographic Details
Published in:BMC anesthesiology 2019-05, Vol.19 (1), p.65-65, Article 65
Main Authors: Vlot, Eline A, Verwijmeren, Lisa, van de Garde, Ewoudt M W, Kloppenburg, Geoffrey T L, van Dongen, Eric P A, Noordzij, Peter G
Format: Article
Language:English
Subjects:
Adults
Aged
Anemia
Anemia - mortality
Anemia - therapy
Aortic valve
Blood products
Blood transfusion
Cardiac patients
Cardiac surgery
Cardiac Surgical Procedures - adverse effects
Cardiac Surgical Procedures - mortality
Care and treatment
Chronic obstructive pulmonary disease
Clinical trials
Cohort Studies
Complications and side effects
Coronary vessels
Erythrocyte Transfusion - adverse effects
Erythrocyte Transfusion - mortality
Erythrocytes
Family medical history
Female
Glycosylated hemoglobin
Heart
Heart surgery
Heart valve diseases
Hemoglobin
Hemoglobins
Hospital Mortality - trends
Hospital patients
Hospitals
Humans
Intraoperative Care - adverse effects
Intraoperative Care - mortality
Male
Medical research
Middle Aged
Mortality
Optimization
Patient outcomes
Patients
Perioperative care
Postoperative Complications - etiology
Postoperative Complications - mortality
Postoperative mortality
R&D
Regression analysis
Research & development
Retrospective Studies
Risk factors
Thoracic surgery
Tranexamic acid
Transfusion
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Summary:Anemia in cardiac surgery patients has been associated with poor outcomes. Transfusion of red blood cells during surgery is common practice for perioperative anemia, but may come with risks. Little is known about the association between intra-operative transfusion and mortality in patients undergoing cardiac surgery. Single centre historical cohort study in 2933 adult patients undergoing coronary surgery with or without aortic valve replacement from June 2011 until September 2014. To estimate the odds ratio for mortality in patients receiving intra-operative transfusion, a propensity score based logistic regression analysis was performed. Intra-operative transfusion was associated with a more than three-fold increased risk of 30-day mortality. Patients in the highest quartile of probability of transfusion were older (age 75 vs 66; P 
ISSN:1471-2253
1471-2253
DOI:10.1186/s12871-019-0738-2