Does a short luteal phase correlate with an increased risk of miscarriage? A cohort study

Miscarriage is defined as spontaneous loss of pregnancy prior to 20 weeks gestation. With an estimated risk of 15% of clinically confirmed pregnancies ending in miscarriage, it is the most common adverse event in pregnancy. Woman's age is the primary risk factor for miscarriage, while medical c...

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Published in:BMC pregnancy and childbirth 2022-12, Vol.22 (1), p.922-9, Article 922
Main Authors: Duane, Marguerite, Schliep, Karen, Porucznik, Christina A, Najmabadi, Shahpar, Stanford, Joseph B
Format: Article
Language:English
Subjects:
Abortion, Spontaneous - epidemiology
Cohort analysis
Cohort Studies
Confounding (Statistics)
Couples
Data analysis
Demographics
Early pregnancy loss
Female
Fertility
Gestational age
Humans
Luteal Phase
Maternal age
Menstruation
Miscarriage
Ovulation
Population
Pregnancy
Progesterone
Sensitivity analysis
Short luteal phase
Variables
Women
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creator Duane, Marguerite
Schliep, Karen
Porucznik, Christina A
Najmabadi, Shahpar
Stanford, Joseph B
description Miscarriage is defined as spontaneous loss of pregnancy prior to 20 weeks gestation. With an estimated risk of 15% of clinically confirmed pregnancies ending in miscarriage, it is the most common adverse event in pregnancy. Woman's age is the primary risk factor for miscarriage, while medical conditions, including hormonal abnormalities, are also associated. Progesterone is essential for maintaining pregnancy. A short luteal phase may reflect inadequate levels of progesterone production, but it is unclear whether a short luteal phase correlates with an increase in the risk of miscarriage. Using a cohort study design, we conducted a secondary data analysis from four cohorts of couples who used a standardized protocol to track biomarkers of the female cycles. A short luteal phase was defined as less than 10 days, with 
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A cohort study</title><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Duane, Marguerite ; Schliep, Karen ; Porucznik, Christina A ; Najmabadi, Shahpar ; Stanford, Joseph B</creator><creatorcontrib>Duane, Marguerite ; Schliep, Karen ; Porucznik, Christina A ; Najmabadi, Shahpar ; Stanford, Joseph B</creatorcontrib><description>Miscarriage is defined as spontaneous loss of pregnancy prior to 20 weeks gestation. With an estimated risk of 15% of clinically confirmed pregnancies ending in miscarriage, it is the most common adverse event in pregnancy. Woman's age is the primary risk factor for miscarriage, while medical conditions, including hormonal abnormalities, are also associated. Progesterone is essential for maintaining pregnancy. A short luteal phase may reflect inadequate levels of progesterone production, but it is unclear whether a short luteal phase correlates with an increase in the risk of miscarriage. Using a cohort study design, we conducted a secondary data analysis from four cohorts of couples who used a standardized protocol to track biomarkers of the female cycles. A short luteal phase was defined as less than 10 days, with &lt; 11, &lt; 9, and &lt; 8 days as alternate definitions in sensitivity analyses. We included women who experienced a pregnancy with a known outcome, identified the length of the luteal phase in up to 3 cycles prior to conception and assessed the relationship with miscarriage using a modified Poisson regression analysis, adjusting for demographic characteristics, smoking, alcohol use and previous pregnancy history. In our sample of 252 women; the overall miscarriage rate was 18.7%. The adjusted incident risk ratio of miscarriage in women who had at least one short luteal phase &lt; 10 days, compared to those who had none, was 1.01 (95% CI: 0.57, 1.80) Similar null risk was found when assessing alternative lengths of short luteal phase. Women who had short luteal phases &lt; 10 days in all 3 cycles prior to the conception cycle had an incident risk ratio of 2.14 (95% CI: 0.7, 6.55). Our study found that a short luteal phase in the three cycles prior to conception was not associated with higher rates of miscarriage in an international cohort of women tracking their cycles, but our sample size was limited. Further research to determine if short luteal phases or luteal phase deficiency is associated with early pregnancy losses among preconception cohorts with daily tracking of cycle parameters, in addition to progesterone and human chorionic gonadotropin levels, is warranted. 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subjects Abortion, Spontaneous - epidemiology
Cohort analysis
Cohort Studies
Confounding (Statistics)
Couples
Data analysis
Demographics
Early pregnancy loss
Female
Fertility
Gestational age
Humans
Luteal Phase
Maternal age
Menstruation
Miscarriage
Ovulation
Population
Pregnancy
Progesterone
Sensitivity analysis
Short luteal phase
Variables
Women
title Does a short luteal phase correlate with an increased risk of miscarriage? A cohort study
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