Methylation of the Vitamin D Receptor Gene in Human Disorders

The Vitamin D Receptor (VDR) mediates the actions of 1,25-Dihydroxvitamin D3 (1,25(OH) D ), which has important roles in bone homeostasis, growth/differentiation of cells, immune functions, and reduction of inflammation. Emerging evidences suggest that epigenetic modifications of the gene, particula...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-12, Vol.25 (1), p.107
Main Authors: Gasperini, Beatrice, Falvino, Angela, Piccirilli, Eleonora, Tarantino, Umberto, Botta, Annalisa, Visconti, Virginia Veronica
Format: Article
Language:English
Subjects:
Alfacalcidol
Antimicrobial agents
Arthritis
Autoimmune diseases
Binding sites
Biomarkers
Calcifediol
Cancer
Communicable diseases
Cytokines
Development and progression
DNA methylation
Enzymes
Epigenetic inheritance
Epigenetics
Genes
HIV
Human immunodeficiency virus
Immune system
Infectious diseases
Methylation
Multiple sclerosis
Peptides
Review
Rheumatoid arthritis
Rheumatoid factor
Tuberculosis
Type 2 diabetes
VDR-related diseases
Vitamin D
vitamin D receptor (VDR)
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Summary:The Vitamin D Receptor (VDR) mediates the actions of 1,25-Dihydroxvitamin D3 (1,25(OH) D ), which has important roles in bone homeostasis, growth/differentiation of cells, immune functions, and reduction of inflammation. Emerging evidences suggest that epigenetic modifications of the gene, particularly DNA methylation, may contribute to the onset and progression of many human disorders. This review aims to summarize the available information on the role of methylation signatures in different pathological contexts, including autoimmune diseases, infectious diseases, cancer, and others. The reversible nature of DNA methylation could enable the development of therapeutic strategies, offering new avenues for the management of these worldwide diseases.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25010107