Deuterium metabolic imaging in the human brain at 9.4 Tesla with high spatial and temporal resolution

• Published in: NeuroImage (Orlando, Fla.) Fla.), 2021-12, Vol.244, p.118639-118639, Article 118639
• Main Authors: Ruhm, Loreen, Avdievich, Nikolai, Ziegs, Theresia, Nagel, Armin M., De Feyter, Henk M., de Graaf, Robin A., Henning, Anke
• Format: Article
• Language: English
• Subjects: 9.4 Tesla; Alzheimer's disease; Brain; Brain - diagnostic imaging; Deuterium; Deuterium - metabolism; DMI; Experiments; Glucose; Glucose - metabolism; Gray Matter - diagnostic imaging; Human brain; Human subjects; Humans; Magnetic Resonance Imaging - methods; Metabolism; Metabolites; Neuroimaging; Oral glucose administration; Software; Spatial discrimination; TCA cycle; Tricarboxylic acid cycle; Volunteers
• ISSN: 1053-8119; 1095-9572
• DOI: 10.1016/j.neuroimage.2021.118639

To present first highly spatially resolved deuterium metabolic imaging (DMI) measurements of the human brain acquired with a dedicated coil design and a fast chemical shift imaging (CSI) sequence at an ultrahigh field strength of B0 = 9.4 T. 2H metabolic measurements with a temporal resolution of 10 min enabled the investigation of the glucose metabolism in healthy human subjects. The study was performed with a double-tuned coil with 10 TxRx channels for 1H and 8TxRx/2Rx channels for 2H and an Ernst angle 3D CSI sequence with a nominal spatial resolution of 2.97 ml and a temporal resolution of 10 min. The metabolism of [6,6′-2H2]-labeled glucose due to the TCA cycle could be made visible in high resolution metabolite images of deuterated water, glucose and Glx over the entire human brain. X-nuclei MRSI as DMI can highly benefit from ultrahigh field strength enabling higher temporal and spatial resolutions.