MUPS Tableting-Comparison between Crospovidone and Microcrystalline Cellulose Core Pellets

Multi-unit pellet system (MUPS) tablets were fabricated by compacting drug-loaded pellets of either crospovidone or microcrystalline cellulose core. These pellets were produced by extrusion-spheronization and coated with ethylcellulose (EC) for a sustained drug release function. Coat damage due to t...

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Bibliographic Details
Published in:Pharmaceutics 2022-12, Vol.14 (12), p.2812
Main Authors: Thio, Daniel Robin, Heng, Paul Wan Sia, Chan, Lai Wah
Format: Article
Language:English
Subjects:
Cellulose
Comparative analysis
crospovidone
Design of experiments
ethylcellulose
Hydrochlorothiazide
Lactose
Materials
MUPS tablet
pellet coat damage
pellet core
Physical properties
Product development
spheronization aid
Tablets (Medicine)
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Summary:Multi-unit pellet system (MUPS) tablets were fabricated by compacting drug-loaded pellets of either crospovidone or microcrystalline cellulose core. These pellets were produced by extrusion-spheronization and coated with ethylcellulose (EC) for a sustained drug release function. Coat damage due to the MUPS tableting process could undermine the sustained release function of the EC-coated pellets. Deformability of the pellet core is a factor that can impact the extent of pellet coat damage. Thus, this study was designed to evaluate the relative performance of drug-loaded pellets prepared with either microcrystalline cellulose (MCC) or crospovidone (XPVP) as a spheronization aid and were comparatively evaluated for their ability to withstand EC pellet coat damage when compacted. These pellets were tableted at various compaction pressures and pellet volume fractions. The extent of pellet coat damage was assessed by the change in drug release after compaction. The findings from this study demonstrated that pellets spheronized with XPVP had slightly less favorable physical properties and experienced comparatively more pellet coat damage than the pellets with MCC. However, MUPS tablets of reasonable quality could successfully be produced from pellets with XPVP, albeit their performance did not match that of vastly mechanically stronger pellets with MCC at higher compaction pressure.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics14122812