Morphological characterization of the hippocampus: a first database in Ecuador

The hippocampal volume is a well-known biomarker to detect and diagnose neurological, psychiatric, and psychological diseases. However, other morphological descriptors are not analyzed. Furthermore, not available databases, or studies, were found with information related to the hippocampal morpholog...

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Bibliographic Details
Published in:Frontiers in human neuroscience 2024-10, Vol.18, p.1387212
Main Authors: Cevallos, Stefano Buitrón, Jerves, Alex X, Vinueza, Clayreth, Hernandez, Dennis, Ávila, Carlos, Auquilla, Andrés, Alvear, Óscar
Format: Article
Language:English
Subjects:
Andean patients
hippocampus
level sets
morphological parameters
MRI
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Summary:The hippocampal volume is a well-known biomarker to detect and diagnose neurological, psychiatric, and psychological diseases. However, other morphological descriptors are not analyzed. Furthermore, not available databases, or studies, were found with information related to the hippocampal morphology from Latin-American patients living in the Andean highlands. The hippocampus is manually segmented by two medical imaging specialists on normal brain magnetic resonance images. Then, its morphological qualitative and quantitative descriptors (volume, sphericity, roundness, diameter, volume-surface ratio, and aspect ratio) are computed via 3D digital level-set-based mathematical representation. Furthermore, other morphological descriptors and their possible correlation with the hippocampal volume is analyzed. We introduce a first database with the hippocampus' morphological characterization of 63 patients from Quito, Ecuador, male and female, aged between 18 and 95 years old. This study provides new research opportunities to neurologists, psychologists, and psychiatrists, to further understand the hippocampal morphology of Andean and Latin American patients.
ISSN:1662-5161
1662-5161
DOI:10.3389/fnhum.2024.1387212