Morphology, composition, and bioactivity of strontium-doped brushite coatings deposited on titanium implants via electrochemical deposition

Surface modification techniques have been applied to generate titanium implant surfaces that promote osseointegration for use in dental applications. In this study, strontium-doped brushite coatings were deposited on titanium by electrochemical deposition. The phase composition of the coating was in...

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Bibliographic Details
Published in:International journal of molecular sciences 2014-06, Vol.15 (6), p.9952-9962
Main Authors: Liang, Yongqiang, Li, Haoyan, Xu, Jiang, Li, Xin, Qi, Mengchun, Hu, Min
Format: Article
Language:English
Subjects:
3T3 Cells
Animals
Biomedical materials
brushite
Calcium Phosphates - chemistry
Calcium Phosphates - metabolism
Cell Proliferation
coating
Dental Implants
Electrochemical Techniques
Female
implant
Materials Testing
Mice
Morphology
Osseointegration
osteoblast
Osteoblasts - cytology
Rats
Rats, Sprague-Dawley
strontium
Strontium - chemistry
Strontium - metabolism
Titanium
Titanium - chemistry
Titanium - metabolism
Transplants & implants
X-Ray Diffraction
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Summary:Surface modification techniques have been applied to generate titanium implant surfaces that promote osseointegration for use in dental applications. In this study, strontium-doped brushite coatings were deposited on titanium by electrochemical deposition. The phase composition of the coating was investigated by energy dispersive X-ray spectroscopy and X-ray diffraction. The surface morphologies of the coatings were studied through scanning electron microscopy, and the cytocompatibility and bioactivity of the strontium-doped brushite coatings were evaluated using cultured osteoblasts. Osteoblast proliferation was enhanced by the addition of strontium, suggesting a possible mechanism by which strontium incorporation in brushite coatings increased bone formation surrounding the implants. Cell growth was also strongly influenced by the composition of the deposited coatings, with a 10% Sr-doped brushite coating inducing the greatest amount of bone formation among the tested materials.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms15069952