Exploring key embryonic developmental morphokinetic parameters that affect clinical outcomes during the PGT cycle using time-lapse monitoring systems

• Published in: BMC pregnancy and childbirth 2024-12, Vol.24 (1), p.870-11, Article 870
• Main Authors: Jiang, Ran, Yang, Guang, Wang, Huihui, Fang, Junnan, Hu, Jingyi, Zhang, Tongwei, Kong, Yue, Wu, Zhaoting, Huang, Xianju, Qi, Lin, Song, Ning, Song, Wenyan, Jin, Haixia, Yao, Guidong
• Format: Article
• Language: English
• Subjects: Adult; Aneuploidy; Blastocyst - physiology; Clinical pregnancy; Embryo quality; Embryonic Development - physiology; Female; Humans; Morphokinetic parameters; Ploidies; Ploidy; Pregnancy; Pregnancy Outcome; Pregnancy Rate; Preimplantation Diagnosis - methods; Preimplantation genetic testing; Retrospective Studies; Single Embryo Transfer - methods; Time-Lapse Imaging; Time-lapse monitoring
• ISSN: 1471-2393; 1471-2393
• DOI: 10.1186/s12884-024-07080-z

Is it possible to predict blastocyst quality, embryo chromosomal ploidy, and clinical pregnancy outcome after single embryo transfer from embryo developmental morphokinetic parameters? The morphokinetic parameters of 1011 blastocysts from 227 patients undergoing preimplantation genetic testing were examined. Correlations between the morphokinetic parameters and the quality of blastocysts, chromosomal ploidy, and clinical pregnancy outcomes following the transfer of single blastocysts were retrospectively analyzed. The morphokinetic parameters of embryos in the high-quality blastocyst group were significantly shorter than those in the low-quality blastocyst group (p