Association of Cutibacterium acnes with human thyroid cancer

The diverse subtypes of thyroid carcinoma have distinct clinical outcomes despite a comparable spectrum of underlying genetic alterations. Beyond genetic alterations, sparse efforts have been made to characterize the microbes associated with thyroid cancer. In this study, we examine the microbial pr...

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Bibliographic Details
Published in:Frontiers in endocrinology (Lausanne) 2023, Vol.14, p.1152514-1152514
Main Authors: Trivedi, Vaishakhi, Noronha, Vanita, Sreekanthreddy, Peddagangannagari, Desai, Sanket, Poojary, Disha, Varghese, Linu, Gowda, Pooja, Butle, Ashwin, Mishra, Rohit, Bal, Munita, Mittal, Neha, Rane, Swapnil, Kane, Shubhada, Basu, Sandip, Patil, Vijay, Menon, Nandini, Singh, Ajay Kumar, Chaturvedi, Pankaj, Chandrani, Pratik, Choughule, Anuradha, Veldore, Vidya, Prabhash, Kumar, Dutt, Amit
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents
Base Sequence
Cutibacterium acnes
Humans
immunosuppression
microbes
pathogen
Propionibacterium acnes - genetics
RNAsequencing
thyroid cancer
Thyroid Neoplasms - epidemiology
Thyroid Neoplasms - genetics
Tumor Microenvironment
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Summary:The diverse subtypes of thyroid carcinoma have distinct clinical outcomes despite a comparable spectrum of underlying genetic alterations. Beyond genetic alterations, sparse efforts have been made to characterize the microbes associated with thyroid cancer. In this study, we examine the microbial profile of thyroid cancer. We sequenced the whole transcriptome of 70 thyroid cancers (40 papillary and 30 anaplastic). Using Infectious Pathogen Detector IPD 2.0, we analysed the relative abundance of 1060 microbes across 70 tumours from patients with thyroid cancer against 118 tumour samples from patients with breast, cervical, colorectal, and tongue cancer. Our analysis reveals a significant prevalence of in 58.6% thyroid cancer samples compared to other cancer types ( ). Immune cell fraction analysis between thyroid cancer samples with high and low loads identify enrichment of immunosuppressive cells, including Tregs ( ), and other anti-inflammatory cytokines in the tumour microenvironment, suggesting an immune evasion/immunosuppression is associated with the infection. A higher burden of was also found to be associated with poor survival defining a distinct sub-group of thyroid cancer. is associated with immune suppression and poor prognosis in a subpopulation of thyroid cancer. This study may help design novel therapeutic measures involving appropriate antibiotics to manage the disease better.
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2023.1152514