Urinary haloacetic acid concentrations in relation to sex and thyroid hormones among reproductive-aged men

Sex and thyroid hormones are critical for male reproductive health. However, the associations between haloacetic acid (HAA) exposure – a known endocrine disruptor – and sex and thyroid hormones in humans remains unclear. We thus recruited 502 male participants seeking fertility evaluation from a rep...

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Bibliographic Details
Published in:Environment international 2024-07, Vol.189, p.108785-108785, Article 108785
Main Authors: Chen, Ying-Jun, Messerlian, Carmen, Lu, Qi, Mustieles, Vicente, Zhang, Yu, Sun, Yang, Wang, Liang, Lu, Wen-Qing, Liu, Chong, Wang, Yi-Xin
Format: Article
Language:English
Subjects:
Acetates
Adult
blood sampling
blood serum
creatinine
dichloroacetic acid
Disinfection by-products
Endocrine Disruptors - blood
Endocrine Disruptors - urine
endocrine-disrupting chemicals
environment
Environmental Exposure - analysis
Environmental Exposure - statistics & numerical data
Epidemiology
estradiol
Gonadal Steroid Hormones - blood
Gonadal Steroid Hormones - urine
Haloacetic acid
Humans
luteinizing hormone
Luteinizing Hormone - blood
Male
males
Middle Aged
regression analysis
sex hormone-binding globulin
Sex Hormone-Binding Globulin - analysis
Sex Hormone-Binding Globulin - metabolism
Sex hormones
testosterone
Testosterone - blood
Testosterone - urine
thyroid function
Thyroid hormones
Thyroid Hormones - blood
Thyrotropin - blood
trichloroacetic acid
Trichloroacetic Acid - blood
Trichloroacetic Acid - urine
urine
Young Adult
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Summary:Sex and thyroid hormones are critical for male reproductive health. However, the associations between haloacetic acid (HAA) exposure – a known endocrine disruptor – and sex and thyroid hormones in humans remains unclear. We thus recruited 502 male participants seeking fertility evaluation from a reproductive center. We measured concentrations of sex and thyroid hormones in a single blood sample and dichloroacetic acid (DCAA) and trichloroacetic acid (TCAA) in repeated urine samples. Multivariable linear regression models were constructed to evaluate the associations between HAA concentrations and hormone measurements. After adjusting for potential confounders and urinary creatinine concentrations, urinary concentrations of TCAA were inversely associated with serum levels of sex hormone-binding globulin (SHBG), testosterone (T), T/luteinizing hormone ratio (T/LH), and thyroid stimulating hormone (TSH) (all P for trend 
ISSN:0160-4120
1873-6750
1873-6750
DOI:10.1016/j.envint.2024.108785