Evaluation of Tissue Expression of Vaspin and Serum Vaspin Concentration as a Prognostic and Risk Factor in Endometrial Cancer

Adipose tissue is a multifunctional endocrine organ. One of the biologically active substances is vaspin, which is part of the serpin family. The purpose of the following study is to determine the possibility of using vaspin as a prognostic and risk factor in endometrial cancer. The study included 1...

Full description

Saved in:
Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2022-10, Vol.11 (20), p.3196
Main Authors: Kozłowski, Mateusz, Pietrzyk, Dominika, Rychlicka, Małgorzata, Piotrowska, Katarzyna, Nowak, Katarzyna, Kwiatkowski, Sebastian, Cymbaluk-Płoska, Aneta
Format: Article
Language:English
Subjects:
Adipokines - blood
Adipokines - metabolism
Adipose tissue
Adipose Tissue - metabolism
Adipose tissues
Biological activity
Body fat
Body mass index
Consent
Cytokines
Diabetes
Endometrial cancer
Endometrial Neoplasms - blood
Endometrial Neoplasms - diagnosis
Endometrium
Estrogens
Female
Gene expression
Genetic aspects
Gynecology
Health aspects
Hormone replacement therapy
Humans
Hyperplasia
Insulin
Laboratories
Lymph nodes
Medical diagnosis
Metabolism
Metabolites
Metastases
Multivariate analysis
Ovaries
Patients
Prognosis
prognostic factor
risk factor
Risk Factors
Serpins - blood
Serpins - metabolism
Thyroid gland
Uterine cancer
Uterus
vaspin
Womens health
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Adipose tissue is a multifunctional endocrine organ. One of the biologically active substances is vaspin, which is part of the serpin family. The purpose of the following study is to determine the possibility of using vaspin as a prognostic and risk factor in endometrial cancer. The study included 127 patients with abnormal uterine bleeding. To determine the value of adipokine, the study used Kaplan-Meier curves to estimate patients survival. Univariate and multivariate analyses were performed simultaneously using the Cox regression model. Tissue expression of vaspin was assessed in patients from the study group (endometrial cancer) and the control group (non-cancerous). We found that higher levels of vaspin are found in obese people, with lower staging (FIGO I and II), lower grading (G1), no LVSI metastases and no lymph node metastases. Higher serum vaspin levels are an independent protective factor for endometrial cancer. We concluded that endometrial cancer patients with serum vaspin concentrations above the median have longer DFS compared to patients with concentrations below the median. Considering multivariate analysis, vaspin concentrations above the median are independent favourable prognostic factors for endometrial cancer. Tissue expression of vaspin cannot be a histological marker to distinguish between cancer and non-cancerous lesions and between different grading levels.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells11203196