Multiple HPV 16 infection with two strains: a possible marker of neoplastic progression

We studied the cases of single and multiple HPV infection and analyzed the correlation with negative cases, and preneoplastic and neoplastic lesions of the uterine cervix with the aim of making a contribution to the prognostic factor under discussion. Nine hundred nine women undergoing second level...

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Bibliographic Details
Published in:BMC cancer 2020-05, Vol.20 (1), p.444-444, Article 444
Main Authors: Bruno, Maria Teresa, Scalia, Guido, Cassaro, Nazario, Boemi, Sara
Format: Article
Language:English
Subjects:
Adolescent
Adult
Alphapapillomavirus - classification
Alphapapillomavirus - genetics
Alphapapillomavirus - isolation & purification
Analysis
Antineoplastic agents
Biopsy
Carcinoma
Cellular biology
Cervical cancer
Cervical Intraepithelial Neoplasia - diagnosis
Cervical Intraepithelial Neoplasia - epidemiology
Cervical Intraepithelial Neoplasia - genetics
Cervical Intraepithelial Neoplasia - virology
Cervix
CIN2
Colposcopy
Cytology
Deoxyribonucleic acid
Development and progression
DNA
Early Detection of Cancer - methods
Female
Follow-Up Studies
Genotype & phenotype
Genotypes
Genotyping
HPV infection
Human papillomavirus
Humans
Infection
Infections
Italy - epidemiology
Lesions
Medical research
Middle Aged
Multiple HPV infection
Papillomavirus infections
Papillomavirus Infections - complications
Papillomavirus Infections - virology
Prevalence studies (Epidemiology)
Prognosis
Retrospective Studies
Statistical analysis
Strains (organisms)
Uterine Cervical Neoplasms - diagnosis
Uterine Cervical Neoplasms - epidemiology
Uterine Cervical Neoplasms - genetics
Uterine Cervical Neoplasms - virology
Uterus
Young Adult
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Summary:We studied the cases of single and multiple HPV infection and analyzed the correlation with negative cases, and preneoplastic and neoplastic lesions of the uterine cervix with the aim of making a contribution to the prognostic factor under discussion. Nine hundred nine women undergoing second level screening because they had been positive at cervical cytology were enrolled. All the patients underwent colposcopy and cervical biopsy with viral genotyping. We divided mHPV infection based on the number of genotypes present: infections with 2 strains, 3 strains, 4 strains and 5 or more strains. The analysis of the data was made using the χ2 test. Contingency tables were created to evaluate the correlation between single, multiple and CIN2+ infections. Values with p 
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-020-06946-7