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Increased incidence of invasive fusariosis with cutaneous portal of entry, Brazil
Invasive fusariosis (IF) is an infection with Fusarium spp. fungi that primarily affects patients with hematologic malignancies and hematopoietic cell transplant recipients. A cutaneous portal of entry is occasionally reported. We reviewed all cases of IF in Brazil during 2000-2010, divided into 2 p...
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Published in: | Emerging infectious diseases 2013-10, Vol.19 (10), p.1567-1572 |
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description | Invasive fusariosis (IF) is an infection with Fusarium spp. fungi that primarily affects patients with hematologic malignancies and hematopoietic cell transplant recipients. A cutaneous portal of entry is occasionally reported. We reviewed all cases of IF in Brazil during 2000-2010, divided into 2 periods: 2000-2005 (period 1) and 2006-2010 (period 2). We calculated incidence rates of IF and of superficial infections with Fusarium spp. fungi identified in patients at a dermatology outpatient unit. IF incidence for periods 1 and 2 was 0.86 cases versus 10.23 cases per 1,000 admissions (p |
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A cutaneous portal of entry is occasionally reported. We reviewed all cases of IF in Brazil during 2000-2010, divided into 2 periods: 2000-2005 (period 1) and 2006-2010 (period 2). We calculated incidence rates of IF and of superficial infections with Fusarium spp. fungi identified in patients at a dermatology outpatient unit. IF incidence for periods 1 and 2 was 0.86 cases versus 10.23 cases per 1,000 admissions (p<0.001), respectively; superficial fusarial infection incidence was 7.23 versus 16.26 positive cultures per 1,000 superficial cultures (p<0.001), respectively. Of 21 cases of IF, 14 showed a primary cutaneous portal of entry. Further studies are needed to identify reservoirs of these fungi in the community and to implement preventive measures for patients at risk.</description><identifier>ISSN: 1080-6040</identifier><identifier>EISSN: 1080-6059</identifier><identifier>DOI: 10.3201/eid1910.120847</identifier><identifier>PMID: 24050318</identifier><language>eng</language><publisher>United States: U.S. National Center for Infectious Diseases</publisher><subject>Blood diseases ; Brazil ; Brazil - epidemiology ; Care and treatment ; CME ; Dermatomycoses - immunology ; Dermatomycoses - microbiology ; Dermatomycoses - mortality ; Diagnosis ; Distribution ; fungi ; Fusariosis - immunology ; Fusariosis - microbiology ; Fusariosis - mortality ; Fusarium ; Health aspects ; Humans ; Immunocompromised Host ; Incidence ; invasive fusariosis ; Leukemia, Myeloid, Acute - immunology ; Mycoses ; portal of entry ; skin</subject><ispartof>Emerging infectious diseases, 2013-10, Vol.19 (10), p.1567-1572</ispartof><rights>COPYRIGHT 2013 U.S. National Center for Infectious Diseases</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c660t-b5aeb01d3d3121e7f6d8658dbb463b1ef6dd78c1f781ad6e5bd513ea1385c1893</citedby><cites>FETCH-LOGICAL-c660t-b5aeb01d3d3121e7f6d8658dbb463b1ef6dd78c1f781ad6e5bd513ea1385c1893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810727/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810727/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24050318$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nucci, Marcio</creatorcontrib><creatorcontrib>Varon, Andrea G</creatorcontrib><creatorcontrib>Garnica, Marcia</creatorcontrib><creatorcontrib>Akiti, Tiyomi</creatorcontrib><creatorcontrib>Barreiros, Gloria</creatorcontrib><creatorcontrib>Trope, Beatriz Moritz</creatorcontrib><creatorcontrib>Nouér, Simone A</creatorcontrib><title>Increased incidence of invasive fusariosis with cutaneous portal of entry, Brazil</title><title>Emerging infectious diseases</title><addtitle>Emerg Infect Dis</addtitle><description>Invasive fusariosis (IF) is an infection with Fusarium spp. fungi that primarily affects patients with hematologic malignancies and hematopoietic cell transplant recipients. A cutaneous portal of entry is occasionally reported. We reviewed all cases of IF in Brazil during 2000-2010, divided into 2 periods: 2000-2005 (period 1) and 2006-2010 (period 2). We calculated incidence rates of IF and of superficial infections with Fusarium spp. fungi identified in patients at a dermatology outpatient unit. IF incidence for periods 1 and 2 was 0.86 cases versus 10.23 cases per 1,000 admissions (p<0.001), respectively; superficial fusarial infection incidence was 7.23 versus 16.26 positive cultures per 1,000 superficial cultures (p<0.001), respectively. Of 21 cases of IF, 14 showed a primary cutaneous portal of entry. Further studies are needed to identify reservoirs of these fungi in the community and to implement preventive measures for patients at risk.</description><subject>Blood diseases</subject><subject>Brazil</subject><subject>Brazil - epidemiology</subject><subject>Care and treatment</subject><subject>CME</subject><subject>Dermatomycoses - immunology</subject><subject>Dermatomycoses - microbiology</subject><subject>Dermatomycoses - mortality</subject><subject>Diagnosis</subject><subject>Distribution</subject><subject>fungi</subject><subject>Fusariosis - immunology</subject><subject>Fusariosis - microbiology</subject><subject>Fusariosis - mortality</subject><subject>Fusarium</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Immunocompromised Host</subject><subject>Incidence</subject><subject>invasive fusariosis</subject><subject>Leukemia, Myeloid, Acute - immunology</subject><subject>Mycoses</subject><subject>portal of entry</subject><subject>skin</subject><issn>1080-6040</issn><issn>1080-6059</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNqNkt9rFDEQxxdRbK2--igLgii4NbPZ3SQvQi1WDwrFn68hm8zupextrkn2tP71zXnn0YN7kDwkM_nMdyaTybLnQE5pSeAdWgMiGVASXrEH2TEQToqG1OLh7lyRo-xJCNeEJArE4-yorEhNKPDj7Mts1B5VQJPbUVuDo8bcdclYqWBXmHdTUN66YEP-y8Z5rqeoRnRTyJfORzWsYRyjv32bf_Dqjx2eZo86NQR8tt1Psh8XH7-ffy4urz7Nzs8uC900JBZtrbAlYKihUAKyrjG8qblp26qhLWCyDeMaOsZBmQbr1tRAUQHltQYu6Ek22-gap67l0tuF8rfSKSv_OpzvpfLR6gFl2QoUugMtWlERLlRLKWFAaiUIaUydtN5vtJZTu0Cj1w9Sw57o_s1o57J3K0k5EFayJPB6K-DdzYQhyoUNGodh0ysJFa1YxQhb53q5QXuVSrNj55KiXuPyjFai4pwynqjiANXjiCm9G7Gzyb3Hnx7g0zK4sPpgwJu9gMRE_B17NYUgZ9--_j979XOffXWPnaMa4jy4YYrWjeFgxdq7EDx2u3YDkevZltvZlpvZTgEv7n_SDv83zPQOonbxeA</recordid><startdate>201310</startdate><enddate>201310</enddate><creator>Nucci, Marcio</creator><creator>Varon, Andrea G</creator><creator>Garnica, Marcia</creator><creator>Akiti, Tiyomi</creator><creator>Barreiros, Gloria</creator><creator>Trope, Beatriz Moritz</creator><creator>Nouér, Simone A</creator><general>U.S. National Center for Infectious Diseases</general><general>Centers for Disease Control and Prevention</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>201310</creationdate><title>Increased incidence of invasive fusariosis with cutaneous portal of entry, Brazil</title><author>Nucci, Marcio ; Varon, Andrea G ; Garnica, Marcia ; Akiti, Tiyomi ; Barreiros, Gloria ; Trope, Beatriz Moritz ; Nouér, Simone A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c660t-b5aeb01d3d3121e7f6d8658dbb463b1ef6dd78c1f781ad6e5bd513ea1385c1893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Blood diseases</topic><topic>Brazil</topic><topic>Brazil - epidemiology</topic><topic>Care and treatment</topic><topic>CME</topic><topic>Dermatomycoses - immunology</topic><topic>Dermatomycoses - microbiology</topic><topic>Dermatomycoses - mortality</topic><topic>Diagnosis</topic><topic>Distribution</topic><topic>fungi</topic><topic>Fusariosis - immunology</topic><topic>Fusariosis - microbiology</topic><topic>Fusariosis - mortality</topic><topic>Fusarium</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Immunocompromised Host</topic><topic>Incidence</topic><topic>invasive fusariosis</topic><topic>Leukemia, Myeloid, Acute - immunology</topic><topic>Mycoses</topic><topic>portal of entry</topic><topic>skin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nucci, Marcio</creatorcontrib><creatorcontrib>Varon, Andrea G</creatorcontrib><creatorcontrib>Garnica, Marcia</creatorcontrib><creatorcontrib>Akiti, Tiyomi</creatorcontrib><creatorcontrib>Barreiros, Gloria</creatorcontrib><creatorcontrib>Trope, Beatriz Moritz</creatorcontrib><creatorcontrib>Nouér, Simone A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Emerging infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nucci, Marcio</au><au>Varon, Andrea G</au><au>Garnica, Marcia</au><au>Akiti, Tiyomi</au><au>Barreiros, Gloria</au><au>Trope, Beatriz Moritz</au><au>Nouér, Simone A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased incidence of invasive fusariosis with cutaneous portal of entry, Brazil</atitle><jtitle>Emerging infectious diseases</jtitle><addtitle>Emerg Infect Dis</addtitle><date>2013-10</date><risdate>2013</risdate><volume>19</volume><issue>10</issue><spage>1567</spage><epage>1572</epage><pages>1567-1572</pages><issn>1080-6040</issn><eissn>1080-6059</eissn><abstract>Invasive fusariosis (IF) is an infection with Fusarium spp. fungi that primarily affects patients with hematologic malignancies and hematopoietic cell transplant recipients. A cutaneous portal of entry is occasionally reported. We reviewed all cases of IF in Brazil during 2000-2010, divided into 2 periods: 2000-2005 (period 1) and 2006-2010 (period 2). We calculated incidence rates of IF and of superficial infections with Fusarium spp. fungi identified in patients at a dermatology outpatient unit. IF incidence for periods 1 and 2 was 0.86 cases versus 10.23 cases per 1,000 admissions (p<0.001), respectively; superficial fusarial infection incidence was 7.23 versus 16.26 positive cultures per 1,000 superficial cultures (p<0.001), respectively. Of 21 cases of IF, 14 showed a primary cutaneous portal of entry. Further studies are needed to identify reservoirs of these fungi in the community and to implement preventive measures for patients at risk.</abstract><cop>United States</cop><pub>U.S. National Center for Infectious Diseases</pub><pmid>24050318</pmid><doi>10.3201/eid1910.120847</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Blood diseases Brazil Brazil - epidemiology Care and treatment CME Dermatomycoses - immunology Dermatomycoses - microbiology Dermatomycoses - mortality Diagnosis Distribution fungi Fusariosis - immunology Fusariosis - microbiology Fusariosis - mortality Fusarium Health aspects Humans Immunocompromised Host Incidence invasive fusariosis Leukemia, Myeloid, Acute - immunology Mycoses portal of entry skin |
title | Increased incidence of invasive fusariosis with cutaneous portal of entry, Brazil |
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